grekovВестник хирургии имени И.И. ГрековаGrekov's Bulletin of Surgery0042-46252686-7370Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation, FSBEI HE I.P.Pavlov SPbSMU MOH Russia10.24884/0042-4625-2019-178-5-132-138grekov-1280Research ArticleОБЗОРЫREVIEWSПЕРИОПЕРАЦИОННЫЕ ИЗМЕНЕНИЯ МИКРОБИОЦЕНОЗА В ХИРУРГИЧЕСКОМ ЛЕЧЕНИИ БОЛЬНЫХ КОЛОРЕКТАЛЬНЫМ РАКОМ (обзор литературы)PERIOPERATIVE CHANGES OF MICROBIOCENOSIS IN SURGICAL TREATMENT OF PATIENTS WITH COLORECTAL CANCER (review of literature)https://orcid.org/0000-0002-8514-5377ЗахаренкоА. А.ZakharenkoA. A.

Захаренко Александр Анатольевич - д-р мед. наук, доцент кафедры онкологии, руководить отдела онкохирургии НИИ хирургии и неотложной медицины

SPIN-код: 3209-8677

Aleksandr A. Zakharenko

9516183@mail.ruhttps://orcid.org/0000-0002-0224-8697СемиглазовВ. В.SemiglazovV. V.

Семиглазов Владислав Владимирович - д-р мед. наук, зав. кафедрой онкологии

Vladislav V. Semiglazov

ssemiglazov@mail.ruhttps://orcid.org/0000-0002-9927-5607ТенО. А.TenO. A.

Тен Олег Андреевич - врач-хирург НИИ хирургии и неотложной медицины

SPIN-код: 7551-8850 AuthorID: 937324

Oleg A. Ten

ten888oleg@mail.ruhttps://orcid.org/0000-0002-1445-7277ДжамиловШ. Р.DjamilovSh. R.

Джамилов Шерали Раджибалиевич - врач-хирург НИИ хирургии и неотложной медицины

SPIN-код:4060-0371

Sherali R. Djamilov

scherali88@mail.ruhttps://orcid.org/0000-0003-0830-3797БеляевМ. А.BelyaevM. A.

Беляев Михаил Алексеевич - канд. мед. наук, руководить отделения абдоминальной онкологии НИИ хирургии и неотложной медицины

SPIN-код: 8885-3644

Mikhail A. Belyaev

mishavma@mail.ruhttps://orcid.org/0000-0003-3086-6457РыбальченкоВ. А.Rybal’chenkoV. A.

Рыбальченко Виталий Александрович - врач-хирург НИИ хирургии и неотложной медицины

SPIN-код: 6517-5793

 

Vitalij A. Rybal’chenko

vitaliirybalchenko@yandex.ruhttps://orcid.org/0000-0002-0224-8697КурсенкоР. В.KursenkoR V.

Курсенко Роман Вадимович - ординатор кафедры факультетской хирургии с курсом лапароскопической и сердечно-сосудистой хирургии

Roman V. Kursenko

romakurss@gmail.comhttps://orcid.org/0000-0002-4131-6293БагненкоС. Ф.BagnenkoS. F.

Багненко Сергей Фёдорович - д-р мед. наук, профессор, академик РАН, ректор

Sergey F. Bagnenko

bagnenko_spb@mail.ruПервый Санкт-Петербургский государственный медицинский университет имени академика И.П.ПавловаРоссияPavlov UniversityRussian Federation2019180920191785132138Copyright © Захаренко А.А., Семиглазов В.В., Тен О.А., Джамилов Ш.Р., Беляев М.А., Рыбальченко В.А., Курсенко Р.В., Багненко С.Ф., 20192019Захаренко А.А., Семиглазов В.В., Тен О.А., Джамилов Ш.Р., Беляев М.А., Рыбальченко В.А., Курсенко Р.В., Багненко С.Ф.Zakharenko A.A., Semiglazov V.V., Ten O.A., Djamilov S.R., Belyaev M.A., Rybal’chenko V.A., Kursenko R.V., Bagnenko S.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vestnik-grekova.ru/jour/article/view/1280

Периоперационные изменения микробиоценоза у онкологических больных – широко исследуемая тема в колоректальной хирургии. В том числе, активно изучается роль микробиоты толстой кишки в развитии гнойно-воспалительных послеоперационных осложнений и ее влияние на возможный рецидив рака. Всю научную литературу в целом можно разделить на несколько тематических групп. Часть рассматриваемых статей посвящена состоянию микробиоты толстой кишки в периоперационный период, ее влиянию на послеоперационные осложнения, в частности, на несостоятельность анастамозов и развитие колита в послеоперационном периоде при дисбиозах. В ряде работ микробиота рассматривается в качестве лечебного инструмента. Также рассматриваются исследования по влиянию антибиотикотерапии на развитие инфекции Clostridium Difficile. Представлен обзор актуальных зарубежных научных исследований микробиоценоза у больных раком толстой кишки, результаты которых могут успешно применяться в отечественной медицинской практике.

Авторы заявили об отсутствии конфликта интересов.

Авторы подтверждают, что соблюдены права людей, принимавших участие в исследовании, включая получение информированного согласия в тех случаях, когда оно необходимо, и правила обращения с животными в случаях их использования в работе. Подробная информация содержится в Правилах для авторов.

Perioperative changes in microbiocenosis in patients with oncological diseases is the widely researched theme in colorectal surgery. In particular, the role of the colon microbiome in the development of purulent-inflammatory postoperative complications and possible significance in cancer disease recurrence have been actively investigated. Data on the colon microbiome tends to be divided on several groups. Part of the considered articles was focused on the condition of the colon microbiome during the perioperative period and its effect on the postoperative complications, in particular on the anastomotic leakage and the development of colitis in the postoperative period in dysbiosis statement. On the other hand, microbiome was evaluated to be a treatment option by the several studies. The effect of antibiotic therapy on the development of Clostridium Difficile infection was investigated as well. The most relevant and up-to-date scientific researches on the microbiocenosis in patients with colorectal cancer were analyzed. The collected data can be used successfully for practical medical using in Russia.

The authors declare no conflict of interest.

The authors confirm that they respect the rights of the people participated in the study, including obtaining informed consent when it is necessary, and the rules of treatment of animals when they are used in the study. Author Guidelines contains the detailed information.

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The authors declare that there are no conflicts of interest present.