grekovВестник хирургии имени И.И. ГрековаGrekov's Bulletin of Surgery0042-4625Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation, FSBEI HE I.P.Pavlov SPbSMU MOH Russia10.24884/0042-4625-2015-174-6-25-28grekov-138Research ArticleВОПРОСЫ ОБЩЕЙ НЕОТЛОЖНОЙ ХИРУРГИИPROBLEMS OF GENERAL AND SPECIAL SURGERYРОЛЬ КИНЕТИЧЕСКИХ ХАРАКТЕРИСТИК ПРОСТАТОСПЕЦИФИЧЕСКОГО АНТИГЕНА ПРИ ОТБОРЕ ПАЦИЕНТОВ ДЛЯ ПРОВЕДЕНИЯ11C-ХОЛИН-ПОЗИТРОННО-ЭМИССИОННОЙ ТОМОГРАФИИ ДЛЯ ВЫЯВЛЕНИЯ МЕСТНЫХ РЕЦИДИВОВ РАКА ПРЕДСТАТЕЛЬНОЙ ЖЕЛЕЗЫROLE OF KINETIC PERFORMANCE OF PSA IN SELECTION OF THE PATIENTS FOR CONDUCTION OF ¹¹C-CHOLINE PET/CT AIMED TO REVEAL LOCAL RECURRENCES OF PROSTATE CANCERРыбаловМ. А.RybalovM. A.maxrybalov@mail.ruДе ЙонгИ. Ян.De IongI. Ya.i.j.de.jong@umcg.nlБреусмаА. Й.BreusmaA. I.a.j.breeuwsma@umcg.nlАль-ШукриС. Х.Al’-ShukriS. Kh.alshukri@mail.ruБоровецС. Ю.BorovetsS. Yu.sborovets@mail.ruПервый Санкт-Петербургский государственный медицинский университет им. акад. И. П. ПавловаРоссияMedical centre of Groningen University; I. P.Pavlov Saint-Petersburg First State Medical UniversityRussian FederationМедицинский центр Университета ГронингенРоссияMedical centre of Groningen UniversityRussian FederationПервый Санкт-Петербургский государственный медицинский университет им. акад. И. П. ПавловаРоссияI. P.Pavlov Saint-Petersburg First State Medical UniversityRussian Federation20152812201517462528Copyright © Рыбалов М.А., Де Йонг И.Я., Бреусма А.Й., Аль-Шукри С.Х., Боровец С.Ю., 20152015Рыбалов М.А., Де Йонг И.Я., Бреусма А.Й., Аль-Шукри С.Х., Боровец С.Ю.Rybalov M.A., De Iong I.Y., Breusma A.I., Al’-Shukri S.K., Borovets S.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vestnik-grekova.ru/jour/article/view/138

Given study was aimed to research a role of kinetic performance of PSA in selection of the patients for conduction ¹¹C-choline PET/CT in order to reveal local recurrences in patient with prostate cancer after radiation therapy (RT) and radical prostatectomy (RP). The study included 185 patients with histologically distinctive prostate cancer and biochemical signs of tumor recurrence after RP (61 patients) or RT (124 patients). All the patients were examined using ¹¹C-choline PET/ CT in order to detect local relapses. Calculation of growth rate of the PSA level and PSA doubling time were made. According to results of ¹¹C-choline PET/CT, recurrences of prostate cancer were detected in 124 out of 185 (65%). There were 22 patients out of 61 (36%) after RP and there were 102 patients out of 124 (82%) after RT. It was stated a correlation between PSA rates, growth rate of PSA level and presence or absence of relapse according to PET/CT results. PSA level and growth rate of PSA were indicated as the most significant predictive signs, which could influence on the selection of the patients for conduction of ¹¹C-choline PET/CT in relation to detection of local recurrence after RT and RP.

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The authors declare that there are no conflicts of interest present.