grekovВестник хирургии имени И.И. ГрековаGrekov's Bulletin of Surgery0042-46252686-7370Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation, FSBEI HE I.P.Pavlov SPbSMU MOH Russia10.24884/0042-4625-2015-174-6-56-59grekov-144Research ArticleНОВЫЕ И РАЦИОНАЛИЗАТОРСКИЕ ПРЕДЛОЖЕНИЯNEW AND RATIONAL SUGGESTIONSЭФФЕКТИВНОСТЬ РАЗЛИЧНЫХ ФОРМ МЕСТНЫХ ГЕМОСТАТИЧЕСКИХ МАТЕРИАЛОВ НА ОСНОВЕ ОКИСЛЕННОЙ ЦЕЛЛЮЛОЗЫ В ЭКСПЕРИМЕНТЕEFFICACY OF DIFFERENT FORMS OF LOCAL HEMOSTATIC MATERIALS BASED ON OXIDIZE CELLULOSE IN THE EXPERIMENTТарковаА. Р.TarkovaA. R.artarkova@mail.ruЧернявскийА. М.ChernyavskiyA. M.amchern@mail.ruГригорьевИ. А.Grigor’EvI. A.grig@nioch.nsc.ruМорозовС. В.MorozovS. V.morozov@nioch.nsc.ruРодионовВ. И.RodionovV. I.virod@nioch.nsc.ruКравченкоН. И.KravchenkoN. I.nikita_ess@mail.ruНовосибирский научно-исследовательский институт патологии кровообращения им. акад. Е. Н. МешалкинаРоссияE. N. Meshalkin Novosibirsk Research Institute of Pathology of Blood CirculationRussian FederationНовосибирский институт органической химии им. Н. Н. ВорожцоваРоссияN. N. Vorozhtsov Novosibirsk Institute of Organic ChemistryRussian Federation20152812201517465659Copyright © Таркова А.Р., Чернявский А.М., Григорьев И.А., Морозов С.В., Родионов В.И., Кравченко Н.И., 20152015Таркова А.Р., Чернявский А.М., Григорьев И.А., Морозов С.В., Родионов В.И., Кравченко Н.И.Tarkova A.R., Chernyavskiy A.M., Grigor’Ev I.A., Morozov S.V., Rodionov V.I., Kravchenko N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vestnik-grekova.ru/jour/article/view/144

The bleeding of intraoperative period is one of the actual problem in surgery. There aren’t any universal hemostatic means in spite of large variety of modern hemostatic methods. An experimental research studied the results of hemostatic activity of different forms of materials on the basis of oxidize cellulose (a gauze, a powder) as compared with their foreign analog (a hemostatic gauze «Surgicel»). Median of hemostasis time consisted of (120±59,9) and (73±46,8) s, in case of application of gauze and powder preparations, respectively. The rate of group using the hemostatic gauze «Surgicel» was (142±77,4) s. The authors made a conclusion on the basis of given research, that the hemostatic material based on oxidize cellulose (the powder form) showed a more expressed hemostatic activity and reliably twice reduced the time of hemostasis as compared with their analog forms of gauze (p<0,05).

кровотечениегемостазокисленная целлюлозаbleedinghemostasisoxidize celluloseReferencesКачмазов А. А., Жернов А. А. Методы гемостаза и применение препаратов из окисленной восстановленной целлюлозы при резекции почки // Экспер. и клин. урол. 2010. № 4. С. 68-71.Качмазов А. А., Жернов А. А. Методы гемостаза и применение препаратов из окисленной восстановленной целлюлозы при резекции почки // Экспер. и клин. урол. 2010. № 4. С. 68-71.Первушин Ю. В., Рогова С. Ш., Ковалевич Н. И. и др. Лабораторные методы исследования системы гемостаза и диагностика нарушений гемокоагуляции. Ставрополь, М.: Москва, 2009. С. 61.Первушин Ю. В., Рогова С. Ш., Ковалевич Н. И. и др. Лабораторные методы исследования системы гемостаза и диагностика нарушений гемокоагуляции. Ставрополь, М.: Москва, 2009. С. 61.Чернявский А. М., Григорьев И. А., Морозов С. В. и др. Контроль локального гемостаза с помощью препаратов окисленной целлюлозы // Хирургия. 2014. № 8. С. 71-75.Чернявский А. М., Григорьев И. А., Морозов С. В. и др. Контроль локального гемостаза с помощью препаратов окисленной целлюлозы // Хирургия. 2014. № 8. С. 71-75.Agarwal M. M., Mandal A. K., Agarwal S. et al. Surgicel granuloma: unusual cause of «recurrent» mass lesion after laparoscopic nephron-sparing surgery for renal cell carcinoma // Urology. 2010. Vol. 76, № 2. P. 334-335.Agarwal M. M., Mandal A. K., Agarwal S. et al. Surgicel granuloma: unusual cause of «recurrent» mass lesion after laparoscopic nephron-sparing surgery for renal cell carcinoma // Urology. 2010. Vol. 76, № 2. P. 334-335.Al-Shaikh S., Muddaiah A., Lee R. J. et al. Oxidised cellulose powder for haemostasis following sinus surgery: a pilot randomised trial // J. Laryngology & Otology. 2014. Vol. 128, № 8. P. 709-713.Al-Shaikh S., Muddaiah A., Lee R. J. et al. Oxidised cellulose powder for haemostasis following sinus surgery: a pilot randomised trial // J. Laryngology & Otology. 2014. Vol. 128, № 8. P. 709-713.Bang B. W., Maeng, J. H., Kim, M. K. et al. Hemostatic action of EGF-endospray on mucosectomy-induced ulcer bleeding animal models // Bio-medical materials and engineering. 2015. Vol. 25, № 1. P. 101-109.Bang B. W., Maeng, J. H., Kim, M. K. et al. Hemostatic action of EGF-endospray on mucosectomy-induced ulcer bleeding animal models // Bio-medical materials and engineering. 2015. Vol. 25, № 1. P. 101-109.Behbehani S., Tulandi T. Oxidized regenerated cellulose imitating pelvic abscess // Obst. Gynecol. 2013. Vol. 121. P. 447-449.Behbehani S., Tulandi T. Oxidized regenerated cellulose imitating pelvic abscess // Obst. Gynecol. 2013. Vol. 121. P. 447-449.Bochicchio G. V., Gupta N., Porte R. J. et al. The finish-3 trial: a phase 3, international, randomized, single-blind, controlled trial of topical fibrocaps in intraoperative surgical hemostasis // J. Amer. Coll. Surg. 2015. Vol. 220, № 1. P. 70-81.Bochicchio G. V., Gupta N., Porte R. J. et al. The finish-3 trial: a phase 3, international, randomized, single-blind, controlled trial of topical fibrocaps in intraoperative surgical hemostasis // J. Amer. Coll. Surg. 2015. Vol. 220, № 1. P. 70-81.Christensen M. C., Dziewior F., Kempel A. et al. Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery // J. Cardiothorac. Vasc. Anesthesia. 2012. Vol. 26, № 1. P. 46-51.Christensen M. C., Dziewior F., Kempel A. et al. Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery // J. Cardiothorac. Vasc. Anesthesia. 2012. Vol. 26, № 1. P. 46-51.Christensen M. C., Krapf S., Kempel A. et al. Costs of excessive postoperative hemorrhage in cardiac surgery // J. Thorac. Cardiovasc. Surg. 2009. Vol. 138, № 3. P. 687-693.Christensen M. C., Krapf S., Kempel A. et al. Costs of excessive postoperative hemorrhage in cardiac surgery // J. Thorac. Cardiovasc. Surg. 2009. Vol. 138, № 3. P. 687-693.Domb A. J., Kost J., Wiseman D. M. Oxidized cellulose: chemistry, processing and medical applications. Handbook of biodegradable polymers. Amsterdam: Harwood Acad. Publ., 1997. P. 291-306.Domb A. J., Kost J., Wiseman D. M. Oxidized cellulose: chemistry, processing and medical applications. Handbook of biodegradable polymers. Amsterdam: Harwood Acad. Publ., 1997. P. 291-306.Glance L. G., Dick A. W., Mukamel D. B. et al. Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery // Surv. Anesthesiol. 2011. Vol. 55, № 6. P. 288-289.Glance L. G., Dick A. W., Mukamel D. B. et al. Association between intraoperative blood transfusion and mortality and morbidity in patients undergoing noncardiac surgery // Surv. Anesthesiol. 2011. Vol. 55, № 6. P. 288-289.Görlinger K., Shore-Lesserson L., Dirkmann D. et al. Management of hemorrhage in cardiothoracic surgery // J. Cardiothorac. Vasc. Anesthes. 2013. Vol. 27, № 4. P. 20-34.Görlinger K., Shore-Lesserson L., Dirkmann D. et al. Management of hemorrhage in cardiothoracic surgery // J. Cardiothorac. Vasc. Anesthes. 2013. Vol. 27, № 4. P. 20-34.Lewis K. M., Atlee H., Mannone A. et al. Efficacy of hemostatic matrix and microporous polysaccharide hemospheres // J. Surg. Res. 2015. Vol. 193, № 2. P. 825-830.Lewis K. M., Atlee H., Mannone A. et al. Efficacy of hemostatic matrix and microporous polysaccharide hemospheres // J. Surg. Res. 2015. Vol. 193, № 2. P. 825-830.Stokes M. E., Ye X., Shah M. et al. Impact of bleeding-related complications and/or blood product transfusions on hospital costs in inpatient surgical patients // BMC health services research. 2011. Vol. 11, № 1. P. 135.Stokes M. E., Ye X., Shah M. et al. Impact of bleeding-related complications and/or blood product transfusions on hospital costs in inpatient surgical patients // BMC health services research. 2011. Vol. 11, № 1. P. 135.Tam T., Harkins G., Dykes. et al. Oxidized regenerated cellulose resembling vaginal cuff abscess // J. Soc. Laparoendoscop. Surg. 2014. Vol. 18, № 2. P. 353.Tam T., Harkins G., Dykes. et al. Oxidized regenerated cellulose resembling vaginal cuff abscess // J. Soc. Laparoendoscop. Surg. 2014. Vol. 18, № 2. P. 353.Tefik T., Sanli O., Oktar et al. Oxidized regenerated cellulose granuloma mimicking recurrent mass lesion after laparoscopic nephron sparing surgery // Int. J. Surg. case reports. 2012. Vol. 3, № 6. P. 227-230.Tefik T., Sanli O., Oktar et al. Oxidized regenerated cellulose granuloma mimicking recurrent mass lesion after laparoscopic nephron sparing surgery // Int. J. Surg. case reports. 2012. Vol. 3, № 6. P. 227-230.Tschan C. A., Nie M., Schwandt E. et al. Safety and efficacy of micro porous polysaccharide hemospheres in neurosurgery // Neuro surgery. 2011. Vol. 69. P. 49-63.Tschan C. A., Nie M., Schwandt E. et al. Safety and efficacy of micro porous polysaccharide hemospheres in neurosurgery // Neuro surgery. 2011. Vol. 69. P. 49-63.Valentine R., Athanasiadis T., Moratti S. et al. The efficacy of a novel chitosan gel on hemostasis and wound healing after endoscopic sinus surgery // Am. J. Rhinol. Fllergy. 2010. Vol. 24, № 1. P. 70-75.Valentine R., Athanasiadis T., Moratti S. et al. The efficacy of a novel chitosan gel on hemostasis and wound healing after endoscopic sinus surgery // Am. J. Rhinol. Fllergy. 2010. Vol. 24, № 1. P. 70-75.Yau A. H. L., Ou G., Galorport C. et al. Safety and efficacy of Hemo spray® in upper gastrointestinal bleeding // Can. J. Gastr. Hepatol. 2014. Vol. 28, № 2. P. 72.Yau A. H. L., Ou G., Galorport C. et al. Safety and efficacy of Hemo spray® in upper gastrointestinal bleeding // Can. J. Gastr. Hepatol. 2014. Vol. 28, № 2. P. 72.Zimnitsky D. S., Yurkshtovich T. L., Bychkovsky P. M. Synthesis and characterization of oxidized cellulose // J. Polymer Sci. Part A: Polymer Chemistry. 2004. Vol. 42, № 19. P. 4785-4791.Zimnitsky D. S., Yurkshtovich T. L., Bychkovsky P. M. Synthesis and characterization of oxidized cellulose // J. Polymer Sci. Part A: Polymer Chemistry. 2004. Vol. 42, № 19. P. 4785-4791.

The authors declare that there are no conflicts of interest present.