grekovВестник хирургии имени И.И. ГрековаGrekov's Bulletin of Surgery0042-4625Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation, FSBEI HE I.P.Pavlov SPbSMU MOH Russia10.24884/0042-4625-2022-181-3-100-107grekov-1804Research ArticleОБЗОРЫREVIEWSПредикторы и классификации степени тяжести острого панкреатитаPredictors and classifications of the degree of severity of acute pancreatitishttps://orcid.org/0000-0002-8456-8685ФедоровА. В.FedorovA. V.

Федоров Андрей Владимирович, доктор медицинских наук, профессор, профессор кафедры эндоскопической хирургии факультета дополнительного профессионального образования

AuthorID: 218681

Москва

Fedorov Andrei V., Dr. of Sci. (Med.), Professor, Professor of the Department of Endoscopic Surgery of the Faculty of Additional Professional Education

Moscow

a.fedorov@surgeons.ruhttps://orcid.org/0000-0001-9422-1776ЭктовВ. Н.EktovV. N.

Эктов Владимир Николаевич, доктор медицинских наук, профессор, заведующий кафедрой хирургических дисциплин Института дополнительного профессионального образования

394036, Воронеж, ул. Студенческая, д. 10

Ektov Vladimir N., Dr. of Sci. (Med.), Professor, Head of the Department of Surgical Disciplines of the Institute of Additional Professional Education

10, Studencheskaya str., Voronezh, 394036

ektov.vladimir@yandex.ruhttps://orcid.org/0000-0003-2584-0471ХодорковскийМ. А.KhodorkovskiyM. A.

Ходорковский Марк Анатольевич, доктор медицинских наук, профессор, профессор кафедры хирургических дисциплин Института дополнительного профессионального образования

 г. Воронеж

Khodorkovskiy Mark A., Dr. of Sci. (Med.), Professor, Professor of the Department of Surgical Disciplines of the Institute of Additional Professional Education

Voronezh

vgmi_30@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Московский государственный медико-стоматологический университет имени А. И. Евдокимова» Министерства здравоохранения Российской ФедерацииРоссияYevdokimov Moscow State University of Medicine and DentistryRussian FederationФедеральное государственное бюджетное образовательное учреждение высшего образования «Воронежский государственный медицинский университет имени Н. Н. Бурденко» Министерства здравоохранения Российской ФедерацииРоссияBurdenko Voronezh State Medical UniversityRussian Federation2022140420221813100107Copyright © Федоров А.В., Эктов В.Н., Ходорковский М.А., 20232023Федоров А.В., Эктов В.Н., Ходорковский М.А.Fedorov A.V., Ektov V.N., Khodorkovskiy M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vestnik-grekova.ru/jour/article/view/1804

Тяжелая форма острого панреатита, относится к опасным для жизни заболеваниям с показателями смертности около 15%. При развитии инфицированного некротизирующего панкреатита, осложненного развитием органной недостаточности, летальность составляет 35,2%. В связи с тем, что острый панкреатит является очень изменчивым патологическим процессом, приводящим к широкому спектру клинических исходов, прогнозирование тяжести заболевания и раннее выявление пациентов с риском развития тяжелых осложнений имеет решающее значение для оптимизации результатов лечения этого заболевания. В настоящее время нет однозначно точных и практически доступных лабораторных тестов для прогнозирования степени тяжести пациентов с острым панкреатитом. В обзоре представлены данные литературы о терминологии и классификациях тяжести острого панкреатита с учетом возможностей их практического применения. Подробно изложена информация о клинических шкальных системах оценки тяжести острого панкреатита с оценкой их эффективности прогнозирования различных исходов лечения. Представлены характеристики и возможности различных лабораторных маркеров в оценке органной недостаточности и диагностике системных осложнений острого панкреатита. По мнению ведущих специалистов, для наилучшей оценки тяжести острого панкреатита необходимо использовать мультидисциплинарное клиническое обследование больных и комбинацию различных инструментов прогнозирования.

Severe acute panreatitis is a life-threatening disease with mortality rates of about 15%. With the development of infected necrotizing pancreatitis, complicated by the development of organ failure, the mortality rate is 35.2%. Due to the fact that acute pancreatitis is a highly variable pathological process, leading to a wide range of clinical outcomes, predicting the severity of the disease and early identification of patients at risk of developing severe complications is critical to optimize treatment outcomes for this disease. Currently, there are no uniquely accurate and practically available laboratory tests to predict the severity of patients with acute pancreatitis. The review presents literature data on the terminology and classifications of the severity of acute pancreatitis, taking into account the possibilities of their practical application. Information on clinical scale systems for assessing the severity of acute pancreatitis with an assessment of their effectiveness in predicting various treatment outcomes is presented in detail. The characteristics and capabilities of various laboratory markers in the assessment of organ failure and diagnosis of systemic complications of acute pancreatitis are presented. Currently, for the best assessment of the severity of acute pancreatitis, it is necessary to use a multidisciplinary clinical examination of patients and a combination of various predictive tools.

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The authors declare that there are no conflicts of interest present.