grekovВестник хирургии имени И.И. ГрековаGrekov's Bulletin of Surgery0042-46252686-7370Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation, FSBEI HE I.P.Pavlov SPbSMU MOH Russia10.24884/0042-4625-2023-182-4-28-32grekov-2046Research ArticleВОПРОСЫ ОБЩЕЙ И ЧАСТНОЙ ХИРУРГИИPROBLEMS OF GENERAL AND SPECIAL SURGERYВлияние сорбента Лигнова на концентрацию интерлейкина-6 в крови и желчи у пациентов с механической желтухой опухолевой этиологииThe effect of Lignova sorbent to the concentration of interleukin-6 in the blood and bile in patients with mechanical jaundice of tumors etiologyhttps://orcid.org/0000-0003-2462-3707АриповаН. У.AripovaN. U.

Ташкент

Aripova Nazira U., Dr. of Sci. (Med.), Professor of the Department of Surgical Diseases 

Tashkent

https://orcid.org/0000-0002-9721-6857ИсмаиловУ. С.IsmailovU. S.

Ташкент

Ismailov Uktam S., Dr. of Sci. (Med.), Professor, Head of the Department of Surgery and Transplantology 

Tashkent

https://orcid.org/0000-0003-1096-835XБаймаковС. Р.BaymakovS. R.

Ташкент

Baymakov Sayfiddin R., Dr. of Sci. (Med.), Professor, Head of the Department of Surgery and Military Field Surgery 

Tashkent

https://orcid.org/0000-0001-7292-3910АдилходжаевА. А.AdilkhodjaevA. A.

Ташкент

Adilkhodjaev Askar A., Dr. of Sci. (Med.), Associate Professor 

Tashkent

https://orcid.org/0000-0001-6767-7241ПулатовМ. М.PulatovM. M.

Ташкент

Pulatov Mirkhakim M., Cand. of Sci. (Med.), Associate Professor of the Department of Surgery and Military Field Surgery 

Tashkent

https://orcid.org/0000-0002-6276-9232МатмуратовС. К.MatmuratovS. K.

Ташкент

Matmuratov Seilkhon K., Cand. of Sci. (Med.), Assistant of the Department of Surgery and Transplantology

Tashkent

https://orcid.org/0000-0002-0483-629XДжамаловС. И.JamalovS. I.

Ташкент

Jamalov Sobir I., Cand. of Sci. (Med.), Associate Professor of the Department of Surgery and Transplantology 

Tashkent

https://orcid.org/0000-0001-6084-8730ЮнусовС. Ш.YunusovS. Sh.

Yunusov Seydamet S., Cand. of Sci. (Med.), Associate Professor of the Department of Surgery and Military Field Surgery

100047, Ташкент, Taraqqiyot ул., д. 103

Yunusov Seydamet Sh., Cand. of Sci. (Med.), Associate Professor of the Department of Surgery and Military Field Surgery

103, Taraqqiyot str., Tashkent, 100047

dr.syu1990@gmail.comТашкентская медицинская академияУзбекистанTashkent Medical AcademyUzbekistanТашкентский государственный стоматологический институтУзбекистанTashkent State Dental InstituteUzbekistanРеспубликанский специализированный научно-практический медицинский центр онкологии и радиологииУзбекистанRepublican Specialized Scientific-practical Medical Center of Oncology and RadiologyUzbekistan20232010202318242832Copyright © Арипова Н.У., Исмаилов У.С., Баймаков С.Р., Адилходжаев А.А., Пулатов М.М., Матмуратов С.К., Джамалов С.И., Юнусов С.Ш., 20242024Арипова Н.У., Исмаилов У.С., Баймаков С.Р., Адилходжаев А.А., Пулатов М.М., Матмуратов С.К., Джамалов С.И., Юнусов С.Ш.Aripova N.U., Ismailov U.S., Baymakov S.R., Adilkhodjaev A.A., Pulatov M.M., Matmuratov S.K., Jamalov S.I., Yunusov S.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vestnik-grekova.ru/jour/article/view/2046

ЦЕЛЬ – изучение изменения концентрации IL-6 в крови и желчи у больных механической желтухой (МЖ) опухолевого генеза методом билиарной сорбции.

МЕТОДЫ И МАТЕРИАЛЫ

МЕТОДЫ И МАТЕРИАЛЫ. Исследование проведено с целью изучения изменения концентрации ИЛ-6 в крови и желчи на фоне сорбции желчи у 105 больных механической желтухой (МЖ), причиной обтурации была опухоль периампулярной зоны. Пациенты разделены на 2 группы. Первую группу составил 51 пациент, вторую группу – 54 пациента. Всем больным основной группы с целью декомпрессии была выполнена чрескожная чреспеченочная холангиостомия; Сорбцию желчи проводили с использованием отечественного энтеросорбента «Лигнов». уровень IL-6 в сыворотке крови и желчи определяли иммуноферментным методом.

РЕЗУЛЬТАТЫ

РЕЗУЛЬТАТЫ. Использование сорбции желчи в комплексе лечения достоверно изменяло концентрацию IL-6 в сыворотке крови (Р<0,01) и желчи. Определение ИЛ-6 в крови и желчи позволяет более объективно оценить степень цитокиновой эндогенной интоксикации в ответ на проводимые лечебные мероприятия при опухолях периампулярной зоны, осложненных механической желтухой. Применение сорбции желчи способствует снижению концентрации провоспалительного цитокина IL-6 в крови и желчи как индуктора эндогенной интоксикации и каскада воспалительных процессов у больных с опухолями периампулярной зоны, осложненными механической желтухой.

ЗАКЛЮЧЕНИЕ

ЗАКЛЮЧЕНИЕ. Применение сорбции желчи способствует снижению концентрации провоспалительного цитокина IL-6 в крови и желчи как индуктора эндогенной интоксикации и каскада воспалительных процессов.

The OBJECTIVE was to study changes of IL-6 concentration in the blood and bile in patients with MJ of tumor genesis by means of biliary sorption.

METHODS AND MATERIALS

METHODS AND MATERIALS. The investigation was conducted to study changes in the concentration of IL-6 in the blood and bile against the background of bile sorption in 105 patients with mechanical jaundice (MJ), the cause of obturation was a tumor of the periampullary zone. The patients are divided into two groups. The first group consisted of 51 patients, the second group included 54 patients. All patients of the main group underwent percutaneous perhepatic cholangiostomy for the purpose of decompression; bile sorption was performed using the domestic Lignov enterosorbent. The level of IL-6 in blood serum and bile was determined by enzyme immunoassay.

RESULTS

RESULTS. The use of bile sorption in the treatment complex significantly changed the concentration of IL-6 in blood serum (P<0.01) and bile. Determination of IL-6 in blood and bile makes it possible to more objectively assess the degree of cytokine-induced endogenous intoxication in response to ongoing therapeutic measures for tumors of the periampullary zone complicated by mechanical jaundice. The use of bile sorption contributes to a decrease in the concentration of the pro-inflammatory cytokine IL-6 in the blood and bile as an inducer of endogenous intoxication and a cascade of inflammatory processes in patients with tumors of the periampullary zone complicated by mechanical jaundice.

CONCLUSION

CONCLUSION. Bile sorption application helps to decrease proinflammatory cytokine IL-6 concentration in blood and bile as an inductor of endogenous intoxication and inflammatory processes cascade.

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The authors declare that there are no conflicts of interest present.