<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">grekov</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник хирургии имени И.И. Грекова</journal-title><trans-title-group xml:lang="en"><trans-title>Grekov's Bulletin of Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0042-4625</issn><issn pub-type="epub">2686-7370</issn><publisher><publisher-name>Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation, FSBEI HE I.P.Pavlov SPbSMU MOH Russia</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/0042-4625-2024-183-3-74-81</article-id><article-id custom-type="elpub" pub-id-type="custom">grekov-2369</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Потенциал клеточной терапии в лечении унивентрикулярных пороков сердца</article-title><trans-title-group xml:lang="en"><trans-title>The  potential of cell therapy in the treatment of univentricular heart defects</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2233-0516</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нохрин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nokhrin</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нохрин Андрей Валерьевич, кандидат медицинских наук, руководитель кардиохирургической службы, заведующий отделением рентгенэндоваскулярной диагностики и лечения, врач сердечно-сосудистый хирург отделения реанимации и интенсивной терапии для детей с кардиохирургической патологией, ассистент кафедры хирургических болезней детского возраста имени Г. А. Баирова</p><p>194100, Санкт-Петербург, ул. Литовская, д. 2</p></bio><bio xml:lang="en"><p>Nokhrin Andrei V., Cand. of Sci. (Med.), Head of the Cardiac Surgery Service, Head of the Department of X-ray Endovascular Diagnostics and Treatment, Cardiovascular Surgeon of the Intensive Care Unit for Children with Cardiac Pathology, Assistant of the Department of Surgical Diseases of Childhood named after G. A. Bairov</p><p>2, Litovskaya str., Saint Petersburg, 194100</p></bio><email xlink:type="simple">nokhrin.andrei@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-5145-2371</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амосова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Amosova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Амосова Анастасия Васильевна, студентка 5 курса педиатрического факультета</p><p>194100, Санкт-Петербург, ул. Литовская, д. 2</p></bio><bio xml:lang="en"><p>Amosova Anastasiia V., 5th year Student of the Faculty of Pediatrics</p><p>2, Litovskaya str., Saint Petersburg, 194100</p></bio><email xlink:type="simple">amosova_01@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-5662-5110</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черепахина</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Cherepakhina</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черепахина Ирина Алексеевна, студентка 5 курса педиатрического факультета</p><p>194100, Санкт-Петербург, ул. Литовская, д. 2</p></bio><bio xml:lang="en"><p>Cherepakhina Irina A., 5th year Student of the Faculty of Pediatrics</p><p>2, Litovskaya str., Saint Petersburg, 194100</p></bio><email xlink:type="simple">cerepahinai088@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9504-5778</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белостоцкая</surname><given-names>Г. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Belostotskaya</surname><given-names>G. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белостоцкая Галина Борисовна, кандидат биологических наук, старший научный сотрудник, руководитель группы цитоанализа</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Belostotskaya Galina B., Cand. of Sci. (Biol.), Senior Research Fellow, Head of the Cytoanalysis Group</p><p>Saint Petersburg</p></bio><email xlink:type="simple">gbelost@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9208-2290</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кулемин</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulemin</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кулемин Евгений Сергеевич, кандидат медицинских наук, зав. операционным отделением, врач – сердечно-сосудистый хирург, ассистент кафедры хирургических болезней детского возраста имени Г. А. Баирова</p><p>194100, Санкт-Петербург, ул. Литовская, д. 2</p></bio><bio xml:lang="en"><p>Kulemin Evgenii S., Cand. of Sci. (Med.), Head of the Department of Surgery, Cardiovascular Surgeon, Assistant of the Department of Surgical Diseases of Childhood named after G. A. Bairov</p><p>2, Litovskaya str., Saint Petersburg, 194100</p></bio><email xlink:type="simple">kulemin.es@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0060-4168</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>Д. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>D. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванов Дмитрий Олегович, ректор</p><p>194100, Санкт-Петербург, ул. Литовская, д. 2</p></bio><bio xml:lang="en"><p>Ivanov Dmitrii O., Rector</p><p>2, Litovskaya str., Saint Petersburg, 194100</p></bio><email xlink:type="simple">cardio.gpmu@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования &#13;
«Санкт-Петербургский государственный педиатрический медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint-Petersburg State Pediatric Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение науки «Институт эволюционной физиологии и биохимии имени И. М. Сеченова» Российской академии наук</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I. M Sechenov Institute of Evolutionary Physiology and Biochemistry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>06</day><month>06</month><year>2024</year></pub-date><volume>183</volume><issue>3</issue><fpage>74</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Нохрин А.В., Амосова А.В., Черепахина И.А., Белостоцкая Г.Б., Кулемин Е.С., Иванов Д.О., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Нохрин А.В., Амосова А.В., Черепахина И.А., Белостоцкая Г.Б., Кулемин Е.С., Иванов Д.О.</copyright-holder><copyright-holder xml:lang="en">Nokhrin A.V., Amosova A.V., Cherepakhina I.A., Belostotskaya G.B., Kulemin E.S., Ivanov D.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vestnik-grekova.ru/jour/article/view/2369">https://www.vestnik-grekova.ru/jour/article/view/2369</self-uri><abstract><p>Единственный желудочек сердца – группа врожденных пороков, которая и на сегодняшний день остается наиболее тяжелой для хирургического лечения и для дальнейшего ведения пациента. Выживаемость пациентов с данным пороком остается относительно невысокой несмотря на проведение ряда этапных оперативных вмешательств. Большой процент смертности наблюдается в межэтапный период ввиду развития сердечной недостаточности, лечение которой является актуальной проблемой, так как стандартная терапия не оправдывает ожидания. В данной статье выполнен обзор мировой литературы о применении инновационного метода коррекции сердечной недостаточности – клеточной терапии. Также рассмотрены основные виды стволовых клеток, источники их получения, механизм действия и методы доставки к миокарду.</p></abstract><trans-abstract xml:lang="en"><p>The single ventricle is a group of congenital heart defects, which even today remains the most difficult for surgical treatment and further patient care. The survival rate of patients with this defect remains relatively low despite a number of staged surgical interventions. A large percentage of mortality is observed in the interstage period due to the development of heart failure, the treatment of which is an urgent problem because standard therapy does not meet expectations. This article reviews the world literature on the application of an innovative method of heart failure correction – stem cell therapy. The main types of stem cells, their sources, mechanism of action, methods of their delivery to myocardium are also considered.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>врожденный порок сердца</kwd><kwd>единственный желудочек сердца</kwd><kwd>клеточная терапия</kwd><kwd>стволовые клетки</kwd><kwd>процедура Норвуда</kwd><kwd>операция Фонтена</kwd></kwd-group><kwd-group xml:lang="en"><kwd>congenital heart disease</kwd><kwd>single ventricle</kwd><kwd>stem cells therapy</kwd><kwd>stem cells</kwd><kwd>Norwood procedure</kwd><kwd>Fontan operation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Meller C. H., Grinenco S., Aiello H. et al. Congenital heart disease, prenatal diagnosis and management. Arch Argent Pediatr. 2020;118(2):e149‒e161.</mixed-citation><mixed-citation xml:lang="en">Meller C. H., Grinenco S., Aiello H. et al. Congenital heart disease, prenatal diagnosis and management. Arch Argent Pediatr. 2020;118(2):e149‒e161.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Bilewska A., Mishra R., Stefanowicz A. et al. Stem cell therapy for single ventricle congenital heart disease ‒ current state and future directions. Postepy w Kardiologii Interwencyjnej. 2022;18(4):319–325.</mixed-citation><mixed-citation xml:lang="en">Bilewska A., Mishra R., Stefanowicz A. et al. Stem cell therapy for single ventricle congenital heart disease ‒ current state and future directions. Postepy w Kardiologii Interwencyjnej. 2022;18(4):319–325.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Williams K., Khan A., Lee Y. S., Hare J. M. et al. Cell-based therapy to boost right ventricular function and cardiovascular performance in hypoplastic left heart syndrome: Current approaches and future directions. Semin Perinatol. 2023;47(3):151725.</mixed-citation><mixed-citation xml:lang="en">Williams K., Khan A., Lee Y. S., Hare J. M. et al. Cell-based therapy to boost right ventricular function and cardiovascular performance in hypoplastic left heart syndrome: Current approaches and future directions. Semin Perinatol. 2023;47(3):151725.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Garbern J. C., Lee R. T. Heart regeneration: 20 years of progress and renewed optimism. Developmental Cell. 2022;57(4):424–439.</mixed-citation><mixed-citation xml:lang="en">Garbern J. C., Lee R. T. Heart regeneration: 20 years of progress and renewed optimism. Developmental Cell. 2022;57(4):424–439.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cho J., Lee H., Rah W. et al. From engineered heart tissue to cardiac organoid. Theranostics. 2022;12(6):2758–2772.</mixed-citation><mixed-citation xml:lang="en">Cho J., Lee H., Rah W. et al. From engineered heart tissue to cardiac organoid. Theranostics. 2022;12(6):2758–2772.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Charitos I. A., Ballini A., Cantore S. et al. Stem cells: a historical review about biological, religious, and ethical issues. Stem Cells International. 2021;2021):9978837.</mixed-citation><mixed-citation xml:lang="en">Charitos I. A., Ballini A., Cantore S. et al. Stem cells: a historical review about biological, religious, and ethical issues. Stem Cells International. 2021;2021):9978837.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Steensma D. P., Kyle R.A. James till and ernest mcculloch: hematopoietic stem cell discoverers. Mayo Clinic Proceedings. 2021;96(3):830–831.</mixed-citation><mixed-citation xml:lang="en">Steensma D. P., Kyle R.A. James till and ernest mcculloch: hematopoietic stem cell discoverers. Mayo Clinic Proceedings. 2021;96(3):830–831.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Brunetti G., Di Benedetto A., Posa F. et al. High expression of TRAIL by osteoblastic differentiated dental pulp stem cells affects myeloma cell viability. Oncol Rep. 2018;39(4):2031–2039.</mixed-citation><mixed-citation xml:lang="en">Brunetti G., Di Benedetto A., Posa F. et al. High expression of TRAIL by osteoblastic differentiated dental pulp stem cells affects myeloma cell viability. Oncol Rep. 2018;39(4):2031–2039.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Qiu C., Ge Z., Cui W. et al. Human amniotic epithelial stem cells: A promising seed cell for clinical applications. International Journal of Molecular Sciences. 2020;21(20):1–26.</mixed-citation><mixed-citation xml:lang="en">Qiu C., Ge Z., Cui W. et al. Human amniotic epithelial stem cells: A promising seed cell for clinical applications. International Journal of Molecular Sciences. 2020;21(20):1–26.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Oh M., Lee J., Kim Y. J. et al. Exosomes derived from human induced pluripotent stem cells ameliorate the aging of skin fibroblasts. Int J Mol Sci. 2018;19(6):1715.</mixed-citation><mixed-citation xml:lang="en">Oh M., Lee J., Kim Y. J. et al. Exosomes derived from human induced pluripotent stem cells ameliorate the aging of skin fibroblasts. Int J Mol Sci. 2018;19(6):1715.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Boccellino M., Di Stasio D., Dipalma G. et al. Steroids and growth factors in oral squamous cell carcinoma: useful source of dental-derived stem cells to develop a steroidogenic model in new clinical strategies. European Review for Medical and Pharmacological Sciences. 2019;23:8730–8740.</mixed-citation><mixed-citation xml:lang="en">Boccellino M., Di Stasio D., Dipalma G. et al. Steroids and growth factors in oral squamous cell carcinoma: useful source of dental-derived stem cells to develop a steroidogenic model in new clinical strategies. European Review for Medical and Pharmacological Sciences. 2019;23:8730–8740.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Tonkin D., Yee-Goh A., Katare R. Healing the ischaemic heart: a critical review of stem cell therapies. Reviews in Cardiovascular Medicine. 2023;24(4):122.</mixed-citation><mixed-citation xml:lang="en">Tonkin D., Yee-Goh A., Katare R. Healing the ischaemic heart: a critical review of stem cell therapies. Reviews in Cardiovascular Medicine. 2023;24(4):122.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Peregud-Pogorzelska M., Przybycień K., Baumert B. et al. The effect of intracoronary infusion of autologous bone marrow-derived lineage-negative stem/progenitor cells on remodeling of post-infarcted heart in patient with acute myocardial infarction. Int J Med Sci. 2020;17(8):985–994.</mixed-citation><mixed-citation xml:lang="en">Peregud-Pogorzelska M., Przybycień K., Baumert B. et al. The effect of intracoronary infusion of autologous bone marrow-derived lineage-negative stem/progenitor cells on remodeling of post-infarcted heart in patient with acute myocardial infarction. Int J Med Sci. 2020;17(8):985–994.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rai V., Gładki M., Dudyńska M. et al. Hypoplastic left heart syndrome [HLHS]: treatment options in present era. Indian Journal of Thoracic and Cardiovascular Surgery. 2019;35(2):196–202.</mixed-citation><mixed-citation xml:lang="en">Rai V., Gładki M., Dudyńska M. et al. Hypoplastic left heart syndrome [HLHS]: treatment options in present era. Indian Journal of Thoracic and Cardiovascular Surgery. 2019;35(2):196–202.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Rychik J., Atz A. M., Celermajer D. S. et al. Evaluation and management of the child and adult with fontan circulation: a scientific statement from the American Heart Association. Circulation. 2019;140(6):E234–E284.</mixed-citation><mixed-citation xml:lang="en">Rychik J., Atz A. M., Celermajer D. S. et al. Evaluation and management of the child and adult with fontan circulation: a scientific statement from the American Heart Association. Circulation. 2019;140(6):E234–E284.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Metcalf M. K., Rychik J. Outcomes in Hypoplastic Left Heart Syndrome // Pediatric Clinics of North America. 2020;67(5):945‒962.</mixed-citation><mixed-citation xml:lang="en">Metcalf M. K., Rychik J. Outcomes in Hypoplastic Left Heart Syndrome // Pediatric Clinics of North America. 2020;67(5):945‒962.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Roeleveld P. P., Axelrod D. M., Klugman D. et al. Hypoplastic left heart syndrome: From fetus to fontan. Cardiol Young. 2018;28(11):1275–1288.</mixed-citation><mixed-citation xml:lang="en">Roeleveld P. P., Axelrod D. M., Klugman D. et al. Hypoplastic left heart syndrome: From fetus to fontan. Cardiol Young. 2018;28(11):1275–1288.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Ramonfaur D., Zhang X., Garza A. P. et al. Hypoplastic left heart syndrome: a review. Cardiology in Review. 2023;31(3):149‒154.</mixed-citation><mixed-citation xml:lang="en">Ramonfaur D., Zhang X., Garza A. P. et al. Hypoplastic left heart syndrome: a review. Cardiology in Review. 2023;31(3):149‒154.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Schranz D., Esmaeili A., Akintuerk H. Hypoplastic left heart: Stage-I will be performed interventionally, soon. Pediatric Cardiology. 2021; 42(4):727‒735.</mixed-citation><mixed-citation xml:lang="en">Schranz D., Esmaeili A., Akintuerk H. Hypoplastic left heart: Stage-I will be performed interventionally, soon. Pediatric Cardiology. 2021; 42(4):727‒735.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Das B. B. Current state of pediatric heart failure. Children. 2018;5(7):88.</mixed-citation><mixed-citation xml:lang="en">Das B. B. Current state of pediatric heart failure. Children. 2018;5(7):88.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia A. M., Beatty J. T., Nakano S. J. et al. Heart failure in single right ventricle congenital heart disease: physiological and molecular considerations. Am J Physiol Heart Circ Physiol. 2020;318(4):H947‒H965.</mixed-citation><mixed-citation xml:lang="en">Garcia A. M., Beatty J. T., Nakano S. J. et al. Heart failure in single right ventricle congenital heart disease: physiological and molecular considerations. Am J Physiol Heart Circ Physiol. 2020;318(4):H947‒H965.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Danton M. H. D. Right ventricular remodelling in hypoplastic left heart syndrome following Fontan completion. European Journal of Cardiothoracic Surgery. 2022;61(1):43‒44.</mixed-citation><mixed-citation xml:lang="en">Danton M. H. D. Right ventricular remodelling in hypoplastic left heart syndrome following Fontan completion. European Journal of Cardiothoracic Surgery. 2022;61(1):43‒44.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Carrillo S. A., Texter K. M., Phelps C. et al. Tricuspid Valve and right ventricular function throughout the hybrid palliation strategy for hypoplastic left heart syndrome and variants. World J Pediatr Congenit Heart Surg. 2021;12(1):9‒16.</mixed-citation><mixed-citation xml:lang="en">Carrillo S. A., Texter K. M., Phelps C. et al. Tricuspid Valve and right ventricular function throughout the hybrid palliation strategy for hypoplastic left heart syndrome and variants. World J Pediatr Congenit Heart Surg. 2021;12(1):9‒16.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tretter J. T., Redington A. N. The forgotten ventricle? The left ventricle in right-sided congenital heart disease. Circ Cardiovasc Imaging. 2018; 11(3):e007410.</mixed-citation><mixed-citation xml:lang="en">Tretter J. T., Redington A. N. The forgotten ventricle? The left ventricle in right-sided congenital heart disease. Circ Cardiovasc Imaging. 2018; 11(3):e007410.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Files M. D., Arya B. Pathophysiology, adaptation, and imaging of the right ventricle in fontan circulation. American Journal of Physiology ‒ Heart and Circulatory Physiology. 2018;315(6):H1779‒H1788.</mixed-citation><mixed-citation xml:lang="en">Files M. D., Arya B. Pathophysiology, adaptation, and imaging of the right ventricle in fontan circulation. American Journal of Physiology ‒ Heart and Circulatory Physiology. 2018;315(6):H1779‒H1788.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy S., Handler S. S., Wu S. et al. Proceedings from the 2019 stanford single ventricle scientific summit: Advancing science for single ventricle patients: From discovery to clinical applications. J Am Heart Assoc. 2020;9(7):e015871.</mixed-citation><mixed-citation xml:lang="en">Reddy S., Handler S. S., Wu S. et al. Proceedings from the 2019 stanford single ventricle scientific summit: Advancing science for single ventricle patients: From discovery to clinical applications. J Am Heart Assoc. 2020;9(7):e015871.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Brida M., Diller G. P., Gatzoulis M. A. Systemic Right Ventricle in Adults with Congenital Heart Disease. Circulation. 2018;137(5):508–518.</mixed-citation><mixed-citation xml:lang="en">Brida M., Diller G. P., Gatzoulis M. A. Systemic Right Ventricle in Adults with Congenital Heart Disease. Circulation. 2018;137(5):508–518.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kajimoto M., Nuri M., Isern N. G. et al. Metabolic response of the immature right ventricle to acute pressure overloading. J Am Heart Assoc. 2018;7(11):e008570.</mixed-citation><mixed-citation xml:lang="en">Kajimoto M., Nuri M., Isern N. G. et al. Metabolic response of the immature right ventricle to acute pressure overloading. J Am Heart Assoc. 2018;7(11):e008570.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Rako Z.A., Kremer N., Yogeswaran A. et al. Adaptive versus maladaptive right ventricular remodelling. ESC Heart Failure. 2023;10(2):762‒775.</mixed-citation><mixed-citation xml:lang="en">Rako Z.A., Kremer N., Yogeswaran A. et al. Adaptive versus maladaptive right ventricular remodelling. ESC Heart Failure. 2023;10(2):762‒775.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Kenny L. A., DeRita F., Nassar M. et al. Transplantation in the single ventricle population. Ann Cardiothorac Surg. 2018;7(1):152‒159.</mixed-citation><mixed-citation xml:lang="en">Kenny L. A., DeRita F., Nassar M. et al. Transplantation in the single ventricle population. Ann Cardiothorac Surg. 2018;7(1):152‒159.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Zwischenberger J. B., Breetz K. A., Ballard-Croft C., Wang D. et al. Failing Fontan cardiovascular support: Review. Journal of Cardiac Surgery. 2022;37(12):5257‒5261.</mixed-citation><mixed-citation xml:lang="en">Zwischenberger J. B., Breetz K. A., Ballard-Croft C., Wang D. et al. Failing Fontan cardiovascular support: Review. Journal of Cardiac Surgery. 2022;37(12):5257‒5261.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Saiki H., Kuwata S., Iwamoto Y. et al. Fenestration in the Fontan circulation as a strategy for chronic cardioprotection. Heart. 2019; 105(16):1266‒1272.</mixed-citation><mixed-citation xml:lang="en">Saiki H., Kuwata S., Iwamoto Y. et al. Fenestration in the Fontan circulation as a strategy for chronic cardioprotection. Heart. 2019; 105(16):1266‒1272.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Schäfer M., Younoszai A., Truong U. et al. Influence of aortic stiffness on ventricular function in patients with Fontan circulation. Journal of Thoracic and Cardiovascular Surgery. 2019;157(2):699‒707.</mixed-citation><mixed-citation xml:lang="en">Schäfer M., Younoszai A., Truong U. et al. Influence of aortic stiffness on ventricular function in patients with Fontan circulation. Journal of Thoracic and Cardiovascular Surgery. 2019;157(2):699‒707.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Devlin P. J., McCrindle B. W., Kirklin J. K. et al. Intervention for arch obstruction after the Norwood procedure: Prevalence, associated factors, and practice variability. Journal of Thoracic and Cardiovascular Surgery. 2019;157(2):684‒695.e8.</mixed-citation><mixed-citation xml:lang="en">Devlin P. J., McCrindle B. W., Kirklin J. K. et al. Intervention for arch obstruction after the Norwood procedure: Prevalence, associated factors, and practice variability. Journal of Thoracic and Cardiovascular Surgery. 2019;157(2):684‒695.e8.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffman G. M., Scott J. P., Ghanayem N. S. et al. Identification of Time-Dependent Risks of Hemodynamic States After Stage 1 Norwood Palliation. Annals of Thoracic Surgery. 2020;109(1):155‒162.</mixed-citation><mixed-citation xml:lang="en">Hoffman G. M., Scott J. P., Ghanayem N. S. et al. Identification of Time-Dependent Risks of Hemodynamic States After Stage 1 Norwood Palliation. Annals of Thoracic Surgery. 2020;109(1):155‒162.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia A. M., Beatty J. T., Nakano S. J. Heart failure in single right ventricle congenital heart disease: Physiological and molecular considerations. American Journal of Physiology ‒ Heart and Circulatory Physiology. 2020;318(4):H947‒H965.</mixed-citation><mixed-citation xml:lang="en">Garcia A. M., Beatty J. T., Nakano S. J. Heart failure in single right ventricle congenital heart disease: Physiological and molecular considerations. American Journal of Physiology ‒ Heart and Circulatory Physiology. 2020;318(4):H947‒H965.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Schütte J. P., Manke M. C., Hemmen K. et al. Platelet-derived MicroRNAs regulate cardiac remodeling after myocardial ischemia. Circ Res. 2023; 132(7):e96‒e113.</mixed-citation><mixed-citation xml:lang="en">Schütte J. P., Manke M. C., Hemmen K. et al. Platelet-derived MicroRNAs regulate cardiac remodeling after myocardial ischemia. Circ Res. 2023; 132(7):e96‒e113.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Belostotskaya G., Hendrikx M., Galagudza M. et al. How to stimulate myocardial regeneration in adult mammalian heart: existing views and new approaches. BioMed Research International. 2020; 2020:7874109.</mixed-citation><mixed-citation xml:lang="en">Belostotskaya G., Hendrikx M., Galagudza M. et al. How to stimulate myocardial regeneration in adult mammalian heart: existing views and new approaches. BioMed Research International. 2020; 2020:7874109.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Karpov A.A., Puzanov M. V., Ivkin D. Y. et al. Non-inferiority of microencapsulated mesenchymal stem cells to free cells in cardiac repair after myocardial infarction: A rationale for using paracrine factor(s) instead of cells. Int J Exp Pathol. 2019;100(2):102‒113.</mixed-citation><mixed-citation xml:lang="en">Karpov A.A., Puzanov M. V., Ivkin D. Y. et al. Non-inferiority of microencapsulated mesenchymal stem cells to free cells in cardiac repair after myocardial infarction: A rationale for using paracrine factor(s) instead of cells. Int J Exp Pathol. 2019;100(2):102‒113.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Belostotskaya G.B., Nerubatskaya I. V., Galagudza M.M. Two mechanisms of cardiac stem cell-mediated cardiomyogenesis in the adult mammalian heart include formation of colonies and cell-in-cell structures. Oncotarget. 2018;9(75):34159‒34175.</mixed-citation><mixed-citation xml:lang="en">Belostotskaya G.B., Nerubatskaya I. V., Galagudza M.M. Two mechanisms of cardiac stem cell-mediated cardiomyogenesis in the adult mammalian heart include formation of colonies and cell-in-cell structures. Oncotarget. 2018;9(75):34159‒34175.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Hyun I., Munsie M., Pera M. F. et al. Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells. Stem Cell Reports. 2020;14(2):169–174.</mixed-citation><mixed-citation xml:lang="en">Hyun I., Munsie M., Pera M. F. et al. Toward Guidelines for Research on Human Embryo Models Formed from Stem Cells. Stem Cell Reports. 2020;14(2):169–174.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Liu G., David B. T., Trawczynski M. et al. Advances in pluripotent stem cells: history, mechanisms, technologies, and applications. Stem Cell Reviews and Reports. 2020;16(1):3–32.</mixed-citation><mixed-citation xml:lang="en">Liu G., David B. T., Trawczynski M. et al. Advances in pluripotent stem cells: history, mechanisms, technologies, and applications. Stem Cell Reviews and Reports. 2020;16(1):3–32.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Sano S., Sano T., Ishigami S., Ito T. Cardiac stem cell therapy: Does a newborn infant’s heart have infinite potential for stem cell therapy? Journal of Thoracic and Cardiovascular Surgery. 2022;163(1):242–247.</mixed-citation><mixed-citation xml:lang="en">Sano S., Sano T., Ishigami S., Ito T. Cardiac stem cell therapy: Does a newborn infant’s heart have infinite potential for stem cell therapy? Journal of Thoracic and Cardiovascular Surgery. 2022;163(1):242–247.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Amdani S., Marino B. S., Rossano J. et al. Burden of pediatric heart failure in the United States. J Am Coll Cardiol. 2022;79(19):1917–1928.</mixed-citation><mixed-citation xml:lang="en">Amdani S., Marino B. S., Rossano J. et al. Burden of pediatric heart failure in the United States. J Am Coll Cardiol. 2022;79(19):1917–1928.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Burkhart H. M., Qureshi M. Y., Rossano J. W. et al. Autologous stem cell therapy for hypoplastic left heart syndrome: Safety and feasibility of intraoperative intramyocardial injections. Journal of Thoracic and Cardiovascular Surgery. 2019;158(6):1614–1623.</mixed-citation><mixed-citation xml:lang="en">Burkhart H. M., Qureshi M. Y., Rossano J. W. et al. Autologous stem cell therapy for hypoplastic left heart syndrome: Safety and feasibility of intraoperative intramyocardial injections. Journal of Thoracic and Cardiovascular Surgery. 2019;158(6):1614–1623.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Зиновьев Е. В., Юдин В. Е., Асадулаев М. С. и др. Опыт применения стволовых клеток при лечении ожогов кожи. Педиатр. 2018. Т. 9, № 4. С. 12–27.</mixed-citation><mixed-citation xml:lang="en">Zinovyev E. V.,Yudin V. E., Asadulaev M. S. et al. Experience of stem cell use in treatment of skin burns. Pediatrician. 2018;9(4):12–27. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Bui T. V. A., Hwang J. W., Lee J. H. et al. Challenges and limitations of strategies to promote therapeutic potential of human mesenchymal stem cells for cell-based cardiac repair. Korean Circulation Journal. 2021;51(2):97–113.</mixed-citation><mixed-citation xml:lang="en">Bui T. V. A., Hwang J. W., Lee J. H. et al. Challenges and limitations of strategies to promote therapeutic potential of human mesenchymal stem cells for cell-based cardiac repair. Korean Circulation Journal. 2021;51(2):97–113.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Pittenger M. F., Discher D. E., Péault B. M. et al. Mesenchymal stem cell perspective: cell biology to clinical progress. Regenerative Medicine. 2019;4(1):22.</mixed-citation><mixed-citation xml:lang="en">Pittenger M. F., Discher D. E., Péault B. M. et al. Mesenchymal stem cell perspective: cell biology to clinical progress. Regenerative Medicine. 2019;4(1):22.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu X., Tang B., Sun Z. Umbilical cord blood transplantation: Still growing and improving. Stem Cells Translational Medicine. 2021;10(S2):S62‒ S74.</mixed-citation><mixed-citation xml:lang="en">Zhu X., Tang B., Sun Z. Umbilical cord blood transplantation: Still growing and improving. Stem Cells Translational Medicine. 2021;10(S2):S62‒ S74.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Nana-Leventaki E., Nana M., Poulianitis N. et al. Cardiosphere-derived cells attenuate inflammation, preserve systolic function, and prevent adverse remodeling in rat hearts with experimental autoimmune myocarditis. J Cardiovasc Pharmacol Ther. 2019;24(1):70–77.</mixed-citation><mixed-citation xml:lang="en">Nana-Leventaki E., Nana M., Poulianitis N. et al. Cardiosphere-derived cells attenuate inflammation, preserve systolic function, and prevent adverse remodeling in rat hearts with experimental autoimmune myocarditis. J Cardiovasc Pharmacol Ther. 2019;24(1):70–77.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Campostrini G., Windt L. M., van Meer B. J. et al. Cardiac tissues from stem cells: new routes to maturation and cardiac regeneration. Circ Res. Lippincott Williams and Wilkins, 2021;128(6):775–801.</mixed-citation><mixed-citation xml:lang="en">Campostrini G., Windt L. M., van Meer B. J. et al. Cardiac tissues from stem cells: new routes to maturation and cardiac regeneration. Circ Res. Lippincott Williams and Wilkins, 2021;128(6):775–801.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Kaushal S., Hare J. M., Hoffman J. R. et al. Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: The ELPIS phase i trial. European Heart Journal Open. 2023;3(2):oead002.</mixed-citation><mixed-citation xml:lang="en">Kaushal S., Hare J. M., Hoffman J. R. et al. Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: The ELPIS phase i trial. European Heart Journal Open. 2023;3(2):oead002.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Mastrangelo F., Scacco S., Ballini A. et al. A pilot study of human mesenchymal stem cells from visceral and sub-cutaneous fat tissue and their differentiation to osteogenic phenotype. Eur Rev Med Pharmacol Sci. 2019;23(7):2924‒2934.</mixed-citation><mixed-citation xml:lang="en">Mastrangelo F., Scacco S., Ballini A. et al. A pilot study of human mesenchymal stem cells from visceral and sub-cutaneous fat tissue and their differentiation to osteogenic phenotype. Eur Rev Med Pharmacol Sci. 2019;23(7):2924‒2934.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Corno A. F., Findley T. O., Salazar J. D. Narrative review of single ventricle: where are we after 40 years? Translational Pediatrics. 2023; 12(2): 221–244.</mixed-citation><mixed-citation xml:lang="en">Corno A. F., Findley T. O., Salazar J. D. Narrative review of single ventricle: where are we after 40 years? Translational Pediatrics. 2023; 12(2): 221–244.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace E., Howard L., Liu M. et al. Long QT syndrome: genetics and future perspective. Pediatric Cardiology. 2019;40(7):1419–1430.</mixed-citation><mixed-citation xml:lang="en">Wallace E., Howard L., Liu M. et al. Long QT syndrome: genetics and future perspective. Pediatric Cardiology. 2019;40(7):1419–1430.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Freud L. R., Seed M. Prenatal diagnosis and management of single-ventricle heart disease. Canadian Journal of Cardiology. 2022; 38(7):897‒908.</mixed-citation><mixed-citation xml:lang="en">Freud L. R., Seed M. Prenatal diagnosis and management of single-ventricle heart disease. Canadian Journal of Cardiology. 2022; 38(7):897‒908.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
