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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">grekov</journal-id><journal-title-group><journal-title xml:lang="ru">Вестник хирургии имени И.И. Грекова</journal-title><trans-title-group xml:lang="en"><trans-title>Grekov's Bulletin of Surgery</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">0042-4625</issn><issn pub-type="epub">2686-7370</issn><publisher><publisher-name>Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation, FSBEI HE I.P.Pavlov SPbSMU MOH Russia</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/0042-4625-2024-183-6-64-70</article-id><article-id custom-type="elpub" pub-id-type="custom">grekov-2542</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Внутрисосудистое лечение острого ишемического инсульта</article-title><trans-title-group xml:lang="en"><trans-title>Current endovascular treatment of acute ischemic stroke</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9715-5505</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кандыба</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kandyba</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандыба Дмитрий Вячеславович, кандидат медицинских наук, главный врач; ассистент кафедры нейрохирургии</p><p>192242, Санкт-Петербург, Будапештская ул., д. 3, лит. А; 194044, Санкт-Петербург, ул. Академика Лебедева, д. 6</p></bio><bio xml:lang="en"><p>Kandyba Dmitriy V., Cand. of Sci. (Med.), Chief Physician;Assistant of the Department of Neurosurgery</p><p>3, Budapeshtskaya str., Saint Petersburg, 192242;6, Academica Lebedeva str., Saint Petersburg, 194044</p></bio><email xlink:type="simple">kandybadv@me.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4797-2937</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бабичев</surname><given-names>К. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Babichev</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бабичев Константин Николаевич, младший научный сотрудник, врач; нейрохирург, клиника нейрохирургии</p><p>192242, Санкт-Петербург, Будапештская ул., д. 3, лит. А; 194044, Санкт-Петербург, ул. Академика Лебедева, д. 6</p></bio><bio xml:lang="en"><p>Babichev Konstantin N., Junior Research Fellow, Doctor; Neurosurgeon, Neurosurgery Clinic</p><p>3, Budapeshtskaya str., Saint Petersburg, 192242;6, Academica Lebedeva str., Saint Petersburg, 194044</p></bio><email xlink:type="simple">k_babichev@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский научно-исследовательский институт скорой помощи им. И. И. Джанелидзе; Военно-медицинская академия имени С. М. Кирова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint-Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine; Military Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>30</day><month>01</month><year>2025</year></pub-date><volume>183</volume><issue>6</issue><fpage>64</fpage><lpage>70</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кандыба Д.В., Бабичев К.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кандыба Д.В., Бабичев К.Н.</copyright-holder><copyright-holder xml:lang="en">Kandyba D.V., Babichev K.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.vestnik-grekova.ru/jour/article/view/2542">https://www.vestnik-grekova.ru/jour/article/view/2542</self-uri><abstract><p>Острый ишемический инсульт является одной из ведущих причин смерти и длительной нетрудоспособности. Долгое время внутривенный тромболизис рекомбинантным активатором плазминогена тканевого типа (rt-PA) был единственным методом лечения пациентов с острым ишемическим инсультом. Однако в настоящее время внутрисосудистые методы лечения позволяют достичь значительно более высоких показателей реканализации и хорошего функционального исхода по сравнению с внутривенной rt-PA у пациентов с ишемическим инсультом вследствие окклюзии крупных церебральных сосудов. В этой статье представлена информация и обсуждается роль внутрисосудистых методов в лечении острого ишемического инсульта.</p></abstract><trans-abstract xml:lang="en"><p>Acute ischemic stroke is one of the leading causes of death and long-term disability. For a long time, intravenous thrombolysis with recombinant tissue-type plasminogen activator (rt-PA) has been the only method of treating patients with acute ischemic stroke. However, at present, endovascular treatment allows to achieve better revascularization and good functional outcomes compared with intravenous rt-PA in patients with ischemic stroke due to large vessel occlusion. This article provides an update and discusses the role of endovascular therapy in management of acute ischemic stroke.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>внутрисосудистое лечение</kwd><kwd>ишемический инсульт</kwd><kwd>тромбэктомия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>endovascular treatment</kwd><kwd>ischemic stroke</kwd><kwd>thrombectomy</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">нет</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Benjamin E. J., Muntner P., Alonso A. et al. American heart association council on epidemiology and prevention statistics committee and stroke statistics subcommittee. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation. 2019. Vol. 139, № 10. P. e56–e528.</mixed-citation><mixed-citation xml:lang="en">Benjamin E. J., Muntner P., Alonso A. et al. American heart association council on epidemiology and prevention statistics committee and stroke statistics subcommittee. Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association. Circulation. 2019;139(10):e56–e528.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Roth G. A., Forouzanfar M. H., Moran A. E. et al. Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med. 2015. Vol. 372, № 14. P. 1333–41. https://doi.org/10.1056/nejmoa1406656.</mixed-citation><mixed-citation xml:lang="en">Roth G. A., Forouzanfar M. H., Moran A. E. et al. Demographic and epidemiologic drivers of global cardiovascular mortality. N Engl J Med. 2015;372(14):1333–41. https://doi.org/10.1056/nejmoa1406656.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Zeumer H., Hacke W., Ringelstein E. B. Local intraarterial thrombolysis in vertebrobasilar thromboembolic disease. AJNR Am J Neuroradiol. 1983. Vol. 4, № 3. P. 401–404. PMID: 641075.</mixed-citation><mixed-citation xml:lang="en">Zeumer H., Hacke W., Ringelstein E. B. Local intraarterial thrombolysis in vertebrobasilar thromboembolic disease. AJNR Am J Neuroradiol. 1983;4(3):401–404. PMID: 641075.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Alexandrov A. V., Molina C. A., Grotta J. C. et al. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med. 2004. Vol. 351. P. 2170–2178. https://doi.org/10.1056/NEJMoa041175.</mixed-citation><mixed-citation xml:lang="en">Alexandrov A. V., Molina C. A., Grotta J. C. et al. Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke. N Engl J Med. 2004; 351:2170–2178. https://doi.org/10.1056/NEJMoa041175.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Furlan A., Higashida R., Wechsler L. et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA. 1999. Vol. 282, № 21. P. 2003–11.</mixed-citation><mixed-citation xml:lang="en">Furlan A., Higashida R., Wechsler L. et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA. 1999;282(21):2003–11.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Ишемический инсульт и транзиторная ишемическая атака у взрослых. Клинические рекомендации. 2021 г.</mixed-citation><mixed-citation xml:lang="en">Ischemic stroke and transient ischemic attack in adults. Clinical recommendations. 2021 г. (In russ.).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Jovin T. G., Chamorro A., Cobo E. et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med. 2015. Vol. 372. P. 2296–2306.</mixed-citation><mixed-citation xml:lang="en">Jovin T. G., Chamorro A., Cobo E. et al. Thrombectomy within 8 hours after symptom onset in ischemic stroke. N Engl J Med. 2015;372:2296–2306.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Saver J. L., Goyal M., Bonafe A. et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015. Vol. 372. P. 2285–2295.</mixed-citation><mixed-citation xml:lang="en">Saver J. L., Goyal M., Bonafe A. et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015; 372:2285–2295.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Goyal M., Demchuk A. M., Menon B. K. et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015. Vol. 372. P. 1019–1030.</mixed-citation><mixed-citation xml:lang="en">Goyal M., Demchuk A. M., Menon B. K. et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015;372:1019–1030.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Berkhemer O. A., Fransen P. S., Beumer D. et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015. Vol. 372. P. 11–20.</mixed-citation><mixed-citation xml:lang="en">Berkhemer O. A., Fransen P. S., Beumer D. et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015;372:11–20.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">2015 AHA/ASA Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment. A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke. 2015. Vol. 46. P. 000-000.</mixed-citation><mixed-citation xml:lang="en">2015 AHA/ASA Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment. A Guideline for Healthcare Professionals from the American Heart Association/American Stroke Association. Stroke. 2015;46:000-000.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Nogueira R. G., Jadhav A. P., Haussen D. C. et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N Engl J Med. 2018. Vol. 378, № 1. P. 11–21. https://doi.org/10.1056/NEJMoa1706442.</mixed-citation><mixed-citation xml:lang="en">Nogueira R. G., Jadhav A. P., Haussen D. C. et al. Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct. N Engl J Med. 2018;378(1):11–21. https://doi.org/10.1056/NEJMoa1706442.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Albers G. W., Marks M. P., Kemp S. et al. Thrombectomy for stroke with perfusion imaging selection at 6–16 hours. N Engl J Med. 2018. Vol. 378. P. 708–18. https://doi.org/10.1056/NEJMoa1713973.</mixed-citation><mixed-citation xml:lang="en">Albers G. W., Marks M. P., Kemp S. et al. Thrombectomy for stroke with perfusion imaging selection at 6–16 hours. N Engl J Med. 2018;378:708– 18. https://doi.org/10.1056/NEJMoa1713973.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Campbell B. C., Mitchell P. J., Kleinig T. J. et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015. Vol. 372. P. 1009–1018.</mixed-citation><mixed-citation xml:lang="en">Campbell B. C., Mitchell P. J., Kleinig T. J. et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372:1009–1018.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Schonewille W. J., Wijman C. A. C., Michel P. et al. Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study. Lancet Neurol. 2009. Vol. 8. P. 724–730. https://doi.org/10.1016/S1474-4422(09)70173-5.</mixed-citation><mixed-citation xml:lang="en">Schonewille W. J., Wijman C. A. C., Michel P. et al. Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study. Lancet Neurol. 2009;8:724–730. https://doi.org/10.1016/S1474-4422(09)70173-5.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Liu X., Dai Q., Ye R. et al. Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial. Lancet Neurol. 2020. Vol. 19. P. 115–122. https://doi.org/10.1016/S1474-4422(19)30395-3.</mixed-citation><mixed-citation xml:lang="en">Liu X., Dai Q., Ye R. et al. Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial. Lancet Neurol. 2020;19:115–122. https://doi.org/10.1016/S1474-4422(19)30395-3.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Tao C., Nogueira R. G., Zhu Y. et al. Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion. N Engl J Med. 2022. Vol. 387, № 15. P. 1361–1372. https://doi.org/10.1056/NEJMoa2206317.</mixed-citation><mixed-citation xml:lang="en">Tao C., Nogueira R. G., Zhu Y. et al. Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion. N Engl J Med. 2022;387(15):1361–1372. https://doi.org/10.1056/NEJMoa2206317.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Jovin T. G., Li C., Wu L. et al. Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion. N Engl J Med. 2022. Vol. 387, № 15. P. 1373–1384. https://doi.org/10.1056/NEJMoa2207576.</mixed-citation><mixed-citation xml:lang="en">Jovin T. G., Li C., Wu L. et al. Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion. N Engl J Med. 2022; 387(15):1373–1384. https://doi.org/10.1056/NEJMoa2207576.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Langezaal L. C. M., van der Hoeven E. J. R. J., Mont’Alverne F. J. A. et al. Endovascular Therapy for Stroke Due to Basilar-Artery Occlusion. N Engl J Med. 2021. Vol. 384, № 20. P. 1910–1920. https://doi.org/10.1056/NEJMoa2030297.</mixed-citation><mixed-citation xml:lang="en">Langezaal L. C. M., van der Hoeven E. J. R. J., Mont’Alverne F. J. A. et al. Endovascular Therapy for Stroke Due to Basilar-Artery Occlusion. N Engl J Med. 2021;384(20):1910–1920. https://doi.org/10.1056/NEJMoa2030297.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
