OBJECTIVE. The authors researched the ways of improvement of treatment results in patients with complicated forms of erysipelas. MATERIAL AND METHODS. There were examined 68 patients with erysipelas complicated by abscess, phlegmon or necrosis of soft tissues. Basic treatment was used for the first group of patients. Combination of basic treatment and application of titanium glycerosolvate aquacomplex were carried out in the second group. Basic treatment and immunomodulator Derinat were applied in the third group. Combined therapy including titanium glycerosolvate aquacomplex and Derinat was used in the fourth group. RESULTS. Prescription of Derinat for patients with erysipelas allowed doctors to eliminate symptoms of general intoxication in more earlier terms compared with сonventional treatment. The application of Derinat stimulated T-and B-сomponents of immune system. The local application of Tizol facilitated to earlier decrease of inflammation and it stimulated regeneration processes in the wound. CONCLUSIONS. The therapy of destructive forms of erysipelas which included Derinat and Tizol shortened the terms of cleansing and repair of purulent wounds. This method increased the efficacy of treatment of given class of patients.