grekovВестник хирургии имени И.И. ГрековаGrekov's Bulletin of Surgery0042-46252686-7370Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation, FSBEI HE I.P.Pavlov SPbSMU MOH Russia10.24884/0042-4625-2017-176-5-10-15grekov-391Research ArticleВОПРОСЫ ОБЩЕЙ НЕОТЛОЖНОЙ ХИРУРГИИPROBLEMS OF GENERAL AND SPECIAL SURGERYФЛЮОРЕСЦЕНТНО-КОНТРОЛИРУЕМАЯ РЕЗЕКЦИЯ ГЛИАЛЬНЫХ ОПУХОЛЕЙ С «ФОТОДИТАЗИНОМ»Fluorescence-guided resection of glioma using «photoditazin»РындаА. Ю.RyndaA. Yu.artemii.rynda@mail.ruРостовцевД. М.RostovtsevD. M.dok79@mail.ruОлюшинВ. Е.OlyushinV. E.Fed_56@mail.ruЗабродскаяЮ. М.ZabrodskayaYu. M.zabrjulia@yandex.ruРоссийский нейрохирургический институт им. проф. А. Л. Поленова; Федеральное государственное бюджетное учреждение «Северо-Западного Федерального медицинского исследовательского центра им. В. А. Алмазова»РоссияA.L. Polenov Russian Neurosurgical InstituteRussian Federation20172810201717651015Copyright © Рында А.Ю., Ростовцев Д.М., Олюшин В.Е., Забродская Ю.М., 20172017Рында А.Ю., Ростовцев Д.М., Олюшин В.Е., Забродская Ю.М.Rynda A.Y., Rostovtsev D.M., Olyushin V.E., Zabrodskaya Y.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vestnik-grekova.ru/jour/article/view/391

ЦЕЛЬ ИССЛЕДОВАНИЯ. Улучшить результаты и радикальность хирургической резекции глиальных опухолей головного мозга. МАТЕРИАЛ И МЕТОДЫ. 31 пациенту с глиальными опухолями разной степени злокачественности выполнена флюоресцентно-контролируемая резекция с использованием препарата «Фотодитазин». Оценивалась эффективность, чувствительность и специфичность метода, степень радикальности резекции применительно к хирургии глиом. РЕЗУЛЬТАТЫ. Для хирургии глиом Grade I-II чувствительность метода составила 68,3 %, специфичность 60,1 %. Для хирургии глиом Grade III-IV чувствительность метода - 85,4 %, специфичность - 76,2 %. Степень достижения GTR (gross total resection) в хирургии глиом Grade I-II - 79,3 %, для хирургии глиом Grade III-IV - 95,6 %. ВЫВОДЫ. Интраоперационная флюоресцентная диагностика с использованием «Фотодитазина» в хирургии глиальных опухолей различной гистологической структуры является высокоэффективным, высокочувствительным и высокоспецифичным методом и позволяет повысить радикальность хирургического удаления глиальных опухолей.

OBJECTIVE. The aim of this research was to improve results of gloss total resections of glial tumors of the brain. MATERIAL AND METHODS. Fluorescence-guided resection was performed in 31 patients with glial tumors of different degree of malignancy. «Photoditazin» was applied during operation. The authors assessed the efficacy, sensitivity and specificity of the method and degree of radical nature of resection in relation to surgery of gliomas. RESULTS. Sensitivity of the method numbered 68,3 % and specificity was 60,1 % in cases of gliomas of grade I-II. It was 85,4 % and 76,2 %, respectively in cases of gliomas of grade III-IV. The degree of achievement of gloss total resection (GTR) was 79,3 % (gliomas of grade III-IV) and 95,6 % (gliomas of grade III-IV). CONCLUSIONS. Intraoperative fluorescent diagnostics using «Photoditazin» was highly effective, sensitive and very specific method in surgery of glial tumors of different degree of malignancy. The method allowed doctors to develop the radical nature of surgery in cases of glial tumors removal.

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The authors declare that there are no conflicts of interest present.