grekovВестник хирургии имени И.И. ГрековаGrekov's Bulletin of Surgery0042-4625Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation, FSBEI HE I.P.Pavlov SPbSMU MOH Russia10.24884/0042-4625-2014-173-4-47-52grekov-553Research ArticleВОПРОСЫ ОБЩЕЙ НЕОТЛОЖНОЙ ХИРУРГИИPROBLEMS OF GENERAL AND SPECIAL SURGERYДИНАМИКА ЛОКАЛЬНОЙ ЭКСПРЕССИИ КОННЕКСИНА-43 И РЕЦЕПТОРОВ ОСНОВНОГО ФАКТОРА РОСТА ФИБРОБЛАСТОВ У БОЛЬНЫХ С ГНОЙНО-ВОСПАЛИТЕЛЬНЫМИ ЗАБОЛЕВАНИЯМИ КОЖИ И МЯГКИХ ТКАНЕЙ НА ФОНЕ САХАРНОГО ДИАБЕТА 2-ГО ТИПАDYNAMICS OF LOCAL EXPRESSION OF CONNEXIN-43 AND BASIC FIBROBLAST GROWTH FACTOR RECEPTORS IN PATIENTS WITH SKIN AND SOFT-TISSUE INFECTIONS AGAINST THE BACKGROUND OF DIABETES MELLITUS TYPE IIВинникЮрий СемёновичVinnikYu. S.yuvinnik@yandex.ruСалминаАлла БорисовнаSalminaA. B.allasalmina@mail.ruТепляковаОльга ВалериевнаTeplyakovaO. V.teplyakova-olga@yandex.ruДробушевскаяАнна ИвановнаDrobushevskayaA. I.annushkadoc@mail.ruМалиновскаяНаталия АлександровнаMalinovskayaN. A.konsuelo81@mail.ruПожиленковаЕлена АнатольевнаPozhilenkovaE. A.pozhilenkova@yandex.ruМоргунАндрей ВасильевичMorgunA. V.441682@mail.ruГитлинаАлла ГеоргиевнаGitlinaA. G.sur-com@yandex.ruКрасноярский государственный медицинский университет им. проф. В. Ф. Войно-ЯсенецкогоРоссияKrasnoyarsk State Medical University named after V.F.Voino-YasenetskiyRussian Federation20141501201817344752Copyright © Винник Ю.С., Салмина А.Б., Теплякова О.В., Дробушевская А.И., Малиновская Н.А., Пожиленкова Е.А., Моргун А.В., Гитлина А.Г., 20182018Винник Ю.С., Салмина А.Б., Теплякова О.В., Дробушевская А.И., Малиновская Н.А., Пожиленкова Е.А., Моргун А.В., Гитлина А.Г.Vinnik Y.S., Salmina A.B., Teplyakova O.V., Drobushevskaya A.I., Malinovskaya N.A., Pozhilenkova E.A., Morgun A.V., Gitlina A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vestnik-grekova.ru/jour/article/view/553

Clinical results of wound healing dynamics were studied in 60 patients with soft-tissue infection against the background of diabetes mellitus type II. At the same time the study considered indices of intercellular contacts protein tissue expression such as connexin 43(Cx43) and basic fibroblast growth factor receptors (bFGFR). The basic therapy of biopsy material of wound borders was applied. The reduction of bFGFR expression and the minor growth of Cx43 expression were observed. The pain syndrome proceeded for a long time and there were signs of perifocal inflammation, retard wound healing with granulation tissue. The application of combined method of ozone therapy which included autohemotherapy with ozone and an external management of wound by ozone-oxygen mixture facilitated to considerable shortening of inflammatory phase and regeneration. It was associated with increased Cx43 expression (in 1,9 times) in comparison with initial level and bFGFR was enlarged in 1,7 times to eighth day of postoperative period.

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The authors declare that there are no conflicts of interest present.