grekovВестник хирургии имени И.И. ГрековаGrekov's Bulletin of Surgery0042-46252686-7370Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation, FSBEI HE I.P.Pavlov SPbSMU MOH Russia10.24884/0042-4625-2014-173-5-64-72grekov-581Research ArticleОПЫТ РАБОТЫEXPERIENCE OF WORKОСОБЕННОСТИ РЕПАРАЦИИ ТКАНЕЙ У ПАЦИЕНТОВ С НЕЙРОПАТИЧЕСКОЙ И НЕЙРОИШЕМИЧЕСКОЙ ФОРМАМИ СИНДРОМА ДИАБЕТИЧЕСКОЙ СТОПЫ НА ФОНЕ ТЕРАПИИ ОТРИЦАТЕЛЬНЫМ ДАВЛЕНИЕМFEATURES OF ANGENESIS AGAINST THE BACKGROUND OF NEGATIVE PRESSURE WOUND THERAPY IN PATIENTS WITH NEUROPATHIC AND NEUROISCHEMIC FORMS OF DIABETIC FOOT ULCERSЗайцеваЕкатерина ЛеонидовнаZaitsevaE. L.zai.kate@gmail.comДоронинаЛюдмила ПетровнаDoroninaL. P.doronina.l@mail.ruМолчковРоман ВахтанговичMolchkovR. V.romanweschapuri@rambler.ruВоронковаИя АлександровнаVoronkovaI. A.iya-v@yandex.ruМитишВалерий АфанасьевичMitishV. A.noemail@neicon.ruТокмаковаАлла ЮрьевнаTokmakovaA. Yu.alla-tokmakova@yandex.ruЭндокринологический центрРоссияEndocrinological Research CentreRussian Federation20141501201817356472Copyright © Зайцева Е.Л., Доронина Л.П., Молчков Р.В., Воронкова И.А., Митиш В.А., Токмакова А.Ю., 20182018Зайцева Е.Л., Доронина Л.П., Молчков Р.В., Воронкова И.А., Митиш В.А., Токмакова А.Ю.Zaitseva E.L., Doronina L.P., Molchkov R.V., Voronkova I.A., Mitish V.A., Tokmakova A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vestnik-grekova.ru/jour/article/view/581

The authors analyzed clinical (size, tissue oxygenation), histological (light microscopy) and immunohistochemical (CD68, MMP-9, TIMP-1) features of reparative processes of soft tissue of lower extremities in patients with diabetes mellitus against the background of vacuum therapy in comparison with standard local treatment. Patients (31 cases) with diabetic foot ulcers were followed-up after surgical d-bridement and before plastic closure of the wound. During perioperative period 13 patients obtained the negative pressure wound therapy (NPWT of 90-120 mmHg) and 18 patients had the standard care. Given results supported higher efficacy of NPWT as compared with standard local care. The therapy caused rapid reduction of wound and its depth, increased local microcirculation and reduced inflammation. These data were confirmed by the histological and immunohistochemical studies. The high efficacy of the method of local treatment could significantly reduce the time of wound preparation for the next step of surgical treatment.

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The authors declare that there are no conflicts of interest present.