An analysis of the results of complex examination and treatment of 181 patients with varicose vein disease (according to CEAP classification C3-C6) was made. Patients were divided into 2 groups. The first group included 106 (58,6%) patients with venous clinical severity score C3 and the second group - 75 (41,4%) patients with score C4-C6. An ultrasonic scintiangiography was used to determine the localization, intensity and length of blow-out in venous system of affected limb. The study found out 2 mechanisms of development of incompetent perforating veins. A superficial blood reflux influenced on the progress of venous insufficiency in 41 (38,7%) patients of the first group. The superficial and deep blood refluxes facilitated to development of the disease and were detected in 67 (89,4%) patients of the second group. It was stated, that there is a direct relation of perforating blood reflux rate with the level of intensity of superficial and deep blood reflux. The more expression of the refluxes took place, the more cases of incompetent perforating veins.