The research included 40 patients with chronic trophic ulcers of lower extremities of different etiology (arterial insufficiency — 14 patients, venous insufficiency — 20 patients, diabetic foot syndrome — 6 people). According to the data of prime bacteriological inoculation, the main pathogens were: gram-positive coccus (Staphylococcus spp., Staphylococcus aureus — 75%, Staphylococcus epidermidis — 7,5%) and yeast-like fungi (Candida albicans — 7,5%). Microbial semination in plentiful quantity (more than 106 KOE) was detected at first inoculation in 85% of the patients. The ointment «Oflomelid» was applied for the patients. After 20 days, the lack of growth and the decrease of contamination level (lower than critical (less than 10² KOE) were noted. A visual analog scale estimated an intensity of pain in patients and it consisted of 39,8% before the treatment, 27,1% — after 10 days, 14,6% — after 20 days. The «Oflomelid» application allowed the reduction of the terms of wound cleansing from nonviable tissues in majority of patients and gained the fast transition from the granulation to epithelization phase. The principle of wound management with the application of ointment «Oflomelid» should be followed in a moist environment. A modern wound dressing must be used after the ointment. This shortened the terms of separate-phase wound repair and decreased the terms of the whole period of trophic ulcers repair in patients with vascular and endocrine pathology.