grekovВестник хирургии имени И.И. ГрековаGrekov's Bulletin of Surgery0042-46252686-7370Federal State Budgetary Educational Institution of Higher Education «Academician I.P. Pavlov First St. Petersburg State Medical University» of the Ministry of Healthcare of the Russion Federation, FSBEI HE I.P.Pavlov SPbSMU MOH Russia10.24884/0042-4625-2015-174-4-13-17grekov-83Research ArticleВОПРОСЫ ОБЩЕЙ НЕОТЛОЖНОЙ ХИРУРГИИPROBLEMS OF GENERAL AND SPECIAL SURGERYИНТРАОПЕРАЦИОНОЕ ОПРЕДЕЛЕНИЕ «СИГНАЛЬНЫХ» ЛИМФАТИЧЕСКИХ УЗЛОВ ПРИ ПОМОЩИ СИСТЕМЫ ИНФРАКРАСНОЙ ВИЗУАЛИЗАЦИИ ПРИ МЕСТНО-РАСПРОСТРАНЁННОМ НЕМЕЛКОКЛЕТОЧНОМ РАКЕ ЛЁГКОГОINTRAOPERATIVE DETECTION OF SENTINEL LYMPH NODES USING INFRARED IMAGING SYSTEM IN LOCAL NON-SMALL CELL CARCINOMA OF LUNGАкоповА. Л.AkopovA. L.akopovand@mail.ruПапаянГ. В.PapayanG. V.papayan.garry632@gmail.comЧистяковИ. В.ChistyakovI. V.iofann@yandex.ruКарлсонА.KarlsonA. ..arulcarlson@gmail.comГерасинА. В.GerasinA. V.avgerasin@inbox.ruАгишевА. С.AgishevA. S.asagishev@yandex.ruПервый Санкт-Петербургский государственный медицинский университет им. акад. И. П. ПавловаРоссияPavlov First Saint-Petersburg State Medical UniversityRussian Federation20152808201517441317Copyright © Акопов А.Л., Папаян Г.В., Чистяков И.В., Карлсон А..., Герасин А.В., Агишев А.С., 20152015Акопов А.Л., Папаян Г.В., Чистяков И.В., Карлсон А., Герасин А.В., Агишев А.С.Akopov A.L., Papayan G.V., Chistyakov I.V., Karlson A..., Gerasin A.V., Agishev A.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.vestnik-grekova.ru/jour/article/view/83

The article presents the results of the first domestic experience of intraoperative fluorescence mapping of sentinel lymph nodes in lung cancer. The research included 10 patients, who underwent surgery over the period of time from September 2013 to May 2014. After performing thoracotomy, the solution of indocyanine green (ICG) was injected using subpleural position above the tumor in 3-4 points. Fluorescence (ICG) image guided surgery was carried out by using infrared radiation (wave length 808 nm) on lung surface, root of lung, mediastinum in real time. Fluorescence lymph nodes were mapped. In case that metastatic lesions weren’t revealed in sentinel lymph nodes, they weren’t noted in other nodes. Method specificity consisted of 100%. Biopsy and histological study of sentinel lymph nodes mapped during fluorescence (ICG) image guided surgery could be useful for prevention of lymphodissection in patients with non-small cell carcinoma of lung.

рак легкогоиндоцианин зеленыйфлюоресценциядиагностика«сигнальный» лимфатический узелlung cancersentinel lymph nodeindocyanine greenfluorescencediagnosticsReferencesАкопов А. Л. Операционная диагностика степени лимфогенного метастазирования рака легкого // Вестн. хир. 2007. № 2. C. 105-109.Акопов А. Л. Операционная диагностика степени лимфогенного метастазирования рака легкого // Вестн. хир. 2007. № 2. C. 105-109.Акопов А. Л., Папаян Г. В., Чистяков И. В. Интраоперационное определение сторожевых лимфатических узлов при раке легкого // Вестн. хир. 2015. № 1. С. 96-102.Акопов А. Л., Папаян Г. В., Чистяков И. В. Интраоперационное определение сторожевых лимфатических узлов при раке легкого // Вестн. хир. 2015. № 1. С. 96-102.Давыдов М. И., Полоцкий Б. Е., Аллахвердиев А. К. Систематическая медиастинальная лимфатическая диссекция - стандарт в хирургическом лечении больных немелкоклеточным раком легкого I, II и IIIа стадии // Пульмонология. 2007. № 3. С. 72-76.Давыдов М. И., Полоцкий Б. Е., Аллахвердиев А. К. Систематическая медиастинальная лимфатическая диссекция - стандарт в хирургическом лечении больных немелкоклеточным раком легкого I, II и IIIа стадии // Пульмонология. 2007. № 3. С. 72-76.Alander J. T., Kaartinen I., Laakso A. et al. Review of indocyanine green fluorescent imaging in surgery // Int. J. Biomed. Imaging. 2012. Vol. 12. P. 1-26.Alander J. T., Kaartinen I., Laakso A. et al. Review of indocyanine green fluorescent imaging in surgery // Int. J. Biomed. Imaging. 2012. Vol. 12. P. 1-26.Chen Z., Zhu N., Pacheco S. et al. Single camera imaging system for color and near-infrared fluorescence image guided surgery // Biomed. optics express. 2014. Vol. 5. P. 2791-2797.Chen Z., Zhu N., Pacheco S. et al. Single camera imaging system for color and near-infrared fluorescence image guided surgery // Biomed. optics express. 2014. Vol. 5. P. 2791-2797.Gilmore D. M., Khullar O. V., Jaklitsch M. T. et al. Identification of metastatic nodal disease in a phase 1 dose-escalation trial of intraoperative sentinel lymph node mapping in non-small cell lung cancer using near-infrared imaging // J. Thorac. Cardiovasc. Surg. 2013. Vol. 146. P. 562-570.Gilmore D. M., Khullar O. V., Jaklitsch M. T. et al. Identification of metastatic nodal disease in a phase 1 dose-escalation trial of intraoperative sentinel lymph node mapping in non-small cell lung cancer using near-infrared imaging // J. Thorac. Cardiovasc. Surg. 2013. Vol. 146. P. 562-570.Halsted W. S. The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June 1889 to January 1894 // J. Hopkins Hosp. Bull. 1894. № 4. P. 297-323.Halsted W. S. The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June 1889 to January 1894 // J. Hopkins Hosp. Bull. 1894. № 4. P. 297-323.Ichinose S., Usuda J., Maehara S. et al. Sentinel node navigation surgery (SNNS) using indocyanine green (ICG) and near infrared spectroscopy in lung cancer // J. Thorac. Oncol. 2009. № 4. P. 563.Ichinose S., Usuda J., Maehara S. et al. Sentinel node navigation surgery (SNNS) using indocyanine green (ICG) and near infrared spectroscopy in lung cancer // J. Thorac. Oncol. 2009. № 4. P. 563.Jain V., Phillips B. T., Conkling N. et al. Sentinel lymph node detection using laser-assisted indocyanine green dye lymphangiography in patients with melanoma // Int. J. Surg. Oncol. 2013. Vol. 13. P. 1-4.Jain V., Phillips B. T., Conkling N. et al. Sentinel lymph node detection using laser-assisted indocyanine green dye lymphangiography in patients with melanoma // Int. J. Surg. Oncol. 2013. Vol. 13. P. 1-4.Kapteijn B. A. E., Nieweg O. E., Peterse J. L. et al. Identification and biopsy of the sentinel lymph node in breast cancer // Eur. J. Surg. Oncol. 1998. Vol. 24. P. 427-430.Kapteijn B. A. E., Nieweg O. E., Peterse J. L. et al. Identification and biopsy of the sentinel lymph node in breast cancer // Eur. J. Surg. Oncol. 1998. Vol. 24. P. 427-430.Lardinois D., Brack T., Gaspert A. et al. Bronchoscopic radioisotope injection for sentinel lymph-node mapping in potentially resectable non-small cell lung cancer // Eur. J. Cardiothorac. Surg. 2003. Vol. 23. P. 824-827.Lardinois D., Brack T., Gaspert A. et al. Bronchoscopic radioisotope injection for sentinel lymph-node mapping in potentially resectable non-small cell lung cancer // Eur. J. Cardiothorac. Surg. 2003. Vol. 23. P. 824-827.Matsuoka H., Kondo K., Takizawa H. et al. Sentinel lymph nodes detection using indocyanine green in patients with lung cancer // J. Thorac. Oncol. 2009. Vol. 4. P. S562-563.Matsuoka H., Kondo K., Takizawa H. et al. Sentinel lymph nodes detection using indocyanine green in patients with lung cancer // J. Thorac. Oncol. 2009. Vol. 4. P. S562-563.Reintgen D. S., Cruse C. W., Wells K. E. et al. The orderly progression of melanoma nodal metastases // Ann. Surg. 1994. Vol. 220. P. 759-767.Reintgen D. S., Cruse C. W., Wells K. E. et al. The orderly progression of melanoma nodal metastases // Ann. Surg. 1994. Vol. 220. P. 759-767.Taghizadeh Kermania A., Bagheri R., Tehranian S. et al. Accuracy of sentinel node biopsy in the staging of non-small cell lung carcinomas: systematic review and meta-analysis of the literature // Lung Cancer. 2013. Vol. 80. P. 5-14.Taghizadeh Kermania A., Bagheri R., Tehranian S. et al. Accuracy of sentinel node biopsy in the staging of non-small cell lung carcinomas: systematic review and meta-analysis of the literature // Lung Cancer. 2013. Vol. 80. P. 5-14.Yamashita S. I., Tokuishi K., Miyawaki M. et al. Sentinel node navigation surgery by thoracoscopic fluorescence imaging system and molecular examination in non-small cell lung cancer // Ann. Surg. Oncol. 2012. Vol. 19. P. 728-733.Yamashita S. I., Tokuishi K., Miyawaki M. et al. Sentinel node navigation surgery by thoracoscopic fluorescence imaging system and molecular examination in non-small cell lung cancer // Ann. Surg. Oncol. 2012. Vol. 19. P. 728-733.

The authors declare that there are no conflicts of interest present.