Morphological and histological changes in the human radial artery in multifocal atherosclerosis
K. M. Mikhailov,
D. V. Kuznetsov,
I. F. Nefedova,
E. N. Nikolaeva,
A. A. Gevorgyan,
V. V. Novokshenov,
A. V. Kryukov,
S. M. Khokhlunov https://doi.org/10.24884/0042-4625-2021-180-5-12-19
Abstract
The OBJECTIVE of our study was to research changes in the radial artery in patients with multifocal atherosclerosis and associated risk factors.
METHODS AND MATERIALS. The object of the study was fragments of the human radial artery extracted during coronary bypass surgery. Patients were divided into 2 main groups: group 1 – patients who, in addition to coronary artery disease, had multifocal atherosclerosis. Group 2 – patients who did not have concomitant lesions of the main arteries. The groups did not differ statistically by gender and age. Morphological and histological studies of the preparations of the radial artery wall were carried out.
RESULTS. The analysis revealed such changes as: edema of one layer of the artery or all three, proliferation of the subendothelial layer of the endarterium, intimal fibrosis, overlap of the artery lumen with a massive accumulation of agglutinated red blood cells, as well as occlusions of the radial artery.
CONCLUSION. Statistical analysis of the results revealed that the combination of the above-mentioned histological factors is an early sign of atherosclerotic lesions of the radial artery wall, as well as confirmed that changes in the radial artery wall are not related to the initial wall thickness and diameter.
About the Authors
K. M. Mikhailov
Samara Regional Clinical Cardiology Dispensary named after V. P. Polyakov
Russian Federation
Competing Interests:
Russian Federation
Mikhaylov Kirill M., Cardiovascular Surgeon of the Cardiac Surgery Department № 11
443070, Samara, Aerodromnaya str., 43
Competing Interests:
The authors declare no conflict of interest.
D. V. Kuznetsov
Samara Regional Clinical Cardiology Dispensary named after V. P. Polyakov; Samara State Medical University
Russian Federation
Competing Interests:
Russian Federation
Kuznetsov Dmitrii V., Cand. of Sci. (Med.), Head of the Cardiac Surgery Department № 11, Samara Regional Clinical Cardiology Dispensary named after V. P. Polyakov; Cardiovascular Surgeon, Assistant of the Department of Cardiology and Cardiovascular surgery of the Institute of Professional Education, Samara State Medical University
Samara
Competing Interests:
The authors declare no conflict of interest.
I. F. Nefedova
Samara State Medical University
Russian Federation
Competing Interests:
Russian Federation
Nefedova Irina F., Research Fellow, Head of the Laboratory of Experimental Morphology, Institute of Experimental Medicine and Biotechnology
Samara
Competing Interests:
The authors declare no conflict of interest.
E. N. Nikolaeva
Samara Regional Clinical Cardiology Dispensary named after V.P. Polyakov
Russian Federation
Competing Interests:
Russian Federation
Nikolaeva Elena N., Head of the Pathology Department
443070, Samara, Aerodromnaya str., 43
Competing Interests:
The authors declare no conflict of interest.
A. A. Gevorgyan
Samara Regional Clinical Cardiology Dispensary named after V.P. Polyakov
Russian Federation
Competing Interests:
Russian Federation
Gevorgyan Arik A., Cardiovascular Surgeon, Cardiac Surgery Department № 11
443070, Samara, Aerodromnaya str., 43
Competing Interests:
The authors declare no conflict of interest.
V. V. Novokshenov
Samara Regional Clinical Cardiology Dispensary named after V.P. Polyakov
Russian Federation
Competing Interests:
Russian Federation
Novokshenov Vyachaslav V., Cardiovascular Surgeon, Cardiac Surgery Department № 11
443070, Samara, Aerodromnaya str., 43
Competing Interests:
The authors declare no conflict of interest.
A. V. Kryukov
Samara Regional Clinical Cardiology Dispensary named after V.P. Polyakov
Russian Federation
Competing Interests:
Russian Federation
Kryukov Andrey V., Cardiovascular Surgeon, Cardiac Surgery Department № 11
443070, Samara, Aerodromnaya str., 43
Competing Interests:
The authors declare no conflict of interest.
S. M. Khokhlunov
Samara State Medical University
Russian Federation
Competing Interests:
Russian Federation
Khohlunov Sergey M., Dr. of Sci. (Med.), Professor, Head of the Department of Cardiology and Cardiovascular Surgery
Samara
Competing Interests:
The authors declare no conflict of interest.
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Mikhailov K.M., Kuznetsov D.V., Nefedova I.F., Nikolaeva E.N., Gevorgyan A.A., Novokshenov V.V., Kryukov A.V., Khokhlunov S.M. Morphological and histological changes in the human radial artery in multifocal atherosclerosis. Grekov's Bulletin of Surgery. 2021;180(5):12-19. (In Russ.) https://doi.org/10.24884/0042-4625-2021-180-5-12-19
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