Leukocyte index of intoxication according to V. K. Ostrovskii as a criterion for assessing bacterial infection

The OBJECTIVE was choose an informative, convenient and accessible in clinical practice index for assessing the level of endogenous intoxication associated with a bacterial infection.

METHODS AND MATERIALS. In the groups of patients with surgical inflammatory bacterial diseases (104 people), with intracellular non-bacterial infection (254 people), and in healthy people (94 people), the degree of LII correlation according to Kalf-Kalif (as a "standard" of indices) was compared with more simple and easy-to-calculate indices: LII according to Ostrovsky, simplified LII according to Ostrovsky ¬ without taking into account plasma cells (sLII according to Ostrovsky), the blood leukocyte shift index according to Yabluchansky, the Harkavy index and the Krebs index.

RESULTS. Within all groups of observations, the closest correlation with LII according to Kalf-Kalif was established for LII according to Ostrovsky, slightly less for LII according to Ostrovsky. The latter was chosen for further study due to the possibility of calculation based on the data of the 5diff automatic blood cell analyzer. Compared with the group of healthy people (1.34 (0.93; 1.59)) sLII according to Ostrovsky did not increase in the group of patients with intracellular non-bacterial infections (1.21 (0.82; 1.49)), moderately increased in subgroup of urological and gynecological patients with chronic local inflammatory processes (2.35 (1.49; 2.99)) and was many times higher in subgroups with acute inflammatory and destructive diseases of the abdominal organs (7.64 (2.05; 11.77 )), sepsis (8.58 (2.96; 13.29)) and septic shock (7.34 (4.07; 9.48)).

CONCLUSION. The calculation of LII according to Ostrovsky or its simplified version without taking into account plasma cells (neutrophils + immature granulocytes)/(lymphocytes + monocytes + eosinophils + basophils) is appropriate and easily applicable in wide clinical practice for assessing a bacterial infection and the development vector of an infectious process.

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