Application of autoplasma enriched with thrombocytes in the comprehensive treatment of acute pancreatitis
https://doi.org/10.24884/0042-4625-2024-183-4-21-27
Abstract
The OBJECTIVE was to assess the proposed treatment method for patients with acute pancreatitis in the 1 A phase of the disease’s development.
METHODS AND MATERIALS. The data from the treatment of patients in the surgical departments of the City Clinical Hospital ¹ 6 in Izhevsk (Clinic of the Department of General Surgery, Izhevsk State Medical Academy) were ana lyzed. Two groups of patients with acute pancreatitis in the 1A phase of the disease development were formed. In the observation group, in addition to the basic treatment, autoplasmic thrombocyte concentrate was administered into the round ligament of the liver. The dynamics of the process and treatment outcomes were assessed based on the criteria scale of primary express assessment of acute pancreatitis severity by the St. Petersburg Research Institute named after I. I. Dzhanelidze (2006), leukocyte index of intoxication by V. K. Ostrovsky (2018), and the J. Ranson scale (1974).
RESULTS. The use of autoplasmic thrombocyte concentrate in the observation group allows reducing the number of minimally invasive interventions to 17.7 %, or by 42.1 %, and the number of laparotomies to 5, or by 54.5 %, compared to the comparison group, avoiding fatal outcomes.
CONCLUSION. The use of autoplasmic thrombocyte concentrate in the comprehensive treatment of patients with acute pancreatitis in the 1 A phase of development and its targeted delivery through the round ligament of the liver allows preventing lethality, reducing the number of complications of acute pancreatitis requiring surgical intervention.
About the Authors
A. Yu. Mikhailov
Izhevsk State Medical Academy
Russian Federation
Competing Interests:
Russian Federation
Mikhailov Alexandr Yu., Cand. of Sci. (Med.), Associate Professor of the Department of General Surgery
281, Kommunarov str., Izhevsk, 426034
Competing Interests:
The authors declare no conflict of interest.
E. V. Khalimov
Izhevsk State Medical Academy
Russian Federation
Competing Interests:
Russian Federation
Khalimov Eduard V., Dr. of Sci. (Med.), Professor of the Department of General Surgery
Izhevsk
Competing Interests:
The authors declare no conflict of interest.
V. V. Remnyakov
Izhevsk State Medical Academy
Russian Federation
Competing Interests:
Russian Federation
Remnyakov Vasilyi V., Postgraduate Student of the Department of General Surgery
Izhevsk
Competing Interests:
The authors declare no conflict of interest.
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Mikhailov A.Yu., Khalimov E.V., Remnyakov V.V. Application of autoplasma enriched with thrombocytes in the comprehensive treatment of acute pancreatitis. Grekov's Bulletin of Surgery. 2024;183(4):21-27. (In Russ.) https://doi.org/10.24884/0042-4625-2024-183-4-21-27
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