C-reactive protein as a predictor of activation of immune-inflammatory processes in the early postoperative period in Crohn’s disease
https://doi.org/10.24884/0042-4625-2025-184-3-47-53
Abstract
The Objective was to study changes in serum C-reactive protein (CRP) concentration in the postoperative period in patients with Crohn’s disease (CD), as well as to substantiate and develop an algorithm for using predictors of inflammation to prevent the possible development of postoperative complications.
Methods and materials. In 62 patients, who underwent surgical interventions performed for CD complications, CRP parameters was studied daily during the first seven days and on the twelfth day of the postoperative period.
Results. In 27.4 % of cases in the postoperative period, CD patients showed activation of the immune-inflammatory process, which increased the risk of postoperative complications. The threshold values of CRP were determined, which can serve as predictors of the activation of immune-inflammatory processes in the early postoperative period in Crohn’s disease.
Conclusion. A pathological increase in CRP on the 3–4th day after surgery should be considered as a predictor of activation of immune-inflammatory processes and as an indication for therapeutic correction.
Supporting agencies: The work was carried out in accordance with the scientific research plan of the Pavlov University. The authors did not receive financial support from manufacturers of medicines and medical equipment.
About the Authors
A. A. Kamanin
Pavlov University
Russian Federation
Competing Interests:
Russian Federation
Kamanin Alexey A., Cand. of Sci. (Med),Associate Professor of the Department of General Surgery with Clinic
6-8, L’va Tolstogo str., Saint Petersburg, 197022
Competing Interests:
The authors declare no conflict of interest.
D. A. Kuznetsova
Pavlov University
Russian Federation
Competing Interests:
Russian Federation
Kuznetsova Daria A., Cand. of Sci. (Med), Leading Research Fellow, Laboratory for the Diagnosis of Autoimmune Diseases of the Scientific and Methodological Center of the Ministry of Health of Russia for Molecular Medicine
6-8, L’va Tolstogo str., Saint Petersburg, 197022
Competing Interests:
The authors declare no conflict of interest.
S. V. Lapin
Pavlov University
Russian Federation
Competing Interests:
Russian Federation
Lapin Sergey V., Cand. of Sci. (Med), Head of the Laboratory for the Diagnosis of Autoimmune Diseases of the Scientific and Methodological Center of the Ministry of Health of Russia for Molecular Medicine
6-8, L’va Tolstogo str., Saint Petersburg, 197022
Competing Interests:
The authors declare no conflict of interest.
A. Yu. Korolkov
Pavlov University
Russian Federation
Competing Interests:
Russian Federation
Korolkov Andrey Yu., Dr. of Sci. (Med), Professor, Head of the Department of Hospital Surgery № 2 with the Clinic named after Academician F. G. Uglova, Head of the Department of General and Emergency Surgery, Research Institute of Surgery and Emergency Medicine
6-8, L’va Tolstogo str., Saint Petersburg, 197022
Competing Interests:
The authors declare no conflict of interest.
V. P. Morozov
Pavlov University
Russian Federation
Competing Interests:
Russian Federation
Morozov Victor P., Dr. of Sci. (Med), Professor, Head of the Department of General Surgery with Clinic
6-8, L’va Tolstogo str., Saint Petersburg, 197022
Competing Interests:
The authors declare no conflict of interest.
S. F. Bagnenko
Pavlov University
Russian Federation
Competing Interests:
Russian Federation
Bagnenko Sergey F., Dr. of Sci. (Med), Academician of the RAS, Rector
6-8, L’va Tolstogo str., Saint Petersburg, 197022
Competing Interests:
The authors declare no conflict of interest.
References
1. Peery A. F., Crocket S. D., Murphy C. C. et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: update 2018. Gastroenterology. 2018;156(1):254–272.
2. GBD 2017 Inflammatory Bowel Disease Collaborators. The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Gastroenterol Hepatol. 2020;(1):17–30.
3. Lewis R. T., Maron D. J. Efficacy and complications of surgery for Crohn’s disease. Gastroenterol Hepatol [NY]. 2010;6:587–96.
4. Fumery M., Seksik P., Auzolle C. et al. Postoperative complications after ileocecal resection in Crohn’s disease: a prospective study from the remind group. Am J Gastroenterol. 2017;112(2):337–345.
5. Vardanyan A. V., Anosov I. S., Michalchenko V. A., Nanaeva B. A. Does the type of anastomosis affect the risk of recurrence in Crohn disease? Koloproktologia. 2023;22(1):83–90. (In Russ.).
6. Calini G., Abdalla S., Abd El Aziz M. A. et al. Ileocolic resection for Crohn’s disease: robotic intracorporeal compared to laparoscopic extracorporeal anastomosis. J Robot Surg. 2023;17(5):2157–2166.
7. Fomin S. A. Analysis of the dynamics of laboratory results in appendectomy from mini-access. Medical Almanac. 2009;(1):103–106. (In Russ.).
8. Garmanova T. N., Agapov M. A., Markaryan D. R. et al. The role of inflammation markers in the early postoperative period for management patients with colorectal cancer. Surgical practice (Russia). 2022;(3):20– 31. (In Russ.).
9. Dudko V. A., Subotsina K. A., Politov I. V. et al. The dynamics of the content of C-reactive protein in blood serum during anesthetic management of surgical interventions. Vestnik VGMU. 2020;19(1):59–65. (In Russ.).
10. Park K. K., Kim T. K., Chang C. B. et al. Normative temporal values of CRP and ESR in unilateral and staged bilateral TKA. Clin Orthop Relat Res. 2008;466(1):179–88.
11. Alsaif S. H., Rogers A. C., Pua P. et al. Preoperative C-reactive protein and other inflammatory markers as predictors of postoperative complications in patients with colorectal neoplasia. World J Surg Oncol. 2021;19(1):74.
12. Velkov V. V. Complex laboratory diagnostics of systemic infections and sepsis: C-reactive protein, procalcitonin, presepsin. Moscow: CJSC “DEACON”, 2015, 117 p. (In Russ.).
Review
For citations:
Kamanin A.A., Kuznetsova D.A., Lapin S.V., Korolkov A.Yu., Morozov V.P., Bagnenko S.F. C-reactive protein as a predictor of activation of immune-inflammatory processes in the early postoperative period in Crohn’s disease. Grekov's Bulletin of Surgery. 2025;184(3):47-53. (In Russ.) https://doi.org/10.24884/0042-4625-2025-184-3-47-53
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