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RESULTS OF RESEARCH OF GALECTIN-3 AND THYROGLOBULIN IN PATIENTS WITH THYROID NODULES

https://doi.org/10.24884/0042-4625-2015-174-2-81-83

Abstract

An investigation of galectin-3 and thyroglobulin using IFA was conducted in 80 patients. A lavage of aspirate from the thyroid gland was obtained by fine-needle aspiration biopsy. It was stated that significant increase of galectin-3 and thyroglobulin was noted in case of high differentiated thyroid carcinoma in comparison with benign nodules. Galectin-3 and thyroglobulin from the lavage of thyroid gland aspirate could be used as an oncological marker for complex differentiated diagnostics of high differentiated thyroid carcinoma and benign nodules.

About the Authors

O. S. Olifirova
Amur State Medical Academy
Russian Federation


S. V. Knalyan
Amur State Medical Academy
Russian Federation


References

1. Камышников В. С. Онкомаркеры: Методы определения, референтные значения, интерпретация тестов: справочник. М.: МЕДпресс-информ, 2012. 128 с.

2. Олифирова О. С., Кналян С. В., Тальченкова Т. Е. и др. Новые возможности в предоперационной диагностике узловых заболеваний щитовидной железы // Бюлл. ВСНЦ СО РАМН. 2012. № 4. Ч. 1. С. 63-67.

3. Сергеева Н. С., Маршутина Н. В. Общие представления о серологических биомаркерах и их месте в онкологии // Практ. онкол. 2011. № 4. С. 147-154.

4. Трошина Е. А., Мазурина Н. В., Абесадзе И. А. и др. Роль молекулярных маркеров в дифференциальной диагностике фолликулярных опухолей щитовидной железы // Клин. и экспер. тиреоидол. 2006. № 2. С. 22-26.

5. Bartolazzi A., Orlandi F., Saggiorato E. et al. Galectin-3-expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicentre study // Lancet Oncol. 2008. Vol. 9, № 6. P. 543-549.

6. Mikosinski S., Pomorski L., Oszukowska L. et al. The diagnostic value of thyroglobulin concentration in fine-needle aspiration of the cervical lymph nodes in patients with differentiated thyroid cancer // Endokrynol. Pol. 2006. Vol. 57, № 4. Р. 392-395.

7. Persoon A. C., Links T. P., Wilde J. et al. Thyroglobulin (Tg) recovery testing with quantitative Tg antibody measurement for determining interference in serum Tg assays in differentiated thyroid carcinoma // Clin. Chem. 2006. Vol. 52, № 6. Р. 1196-1169.

8. Spencer C. A. Challenges of serum thyroglobulin (Tg) measurement in the presence of Tg autoantibodies // J. Clin. Endocrinol. Metab. 2004. Vol. 89, № 8. Р. 3702-3704.


Review

For citations:


Olifirova O.S., Knalyan S.V. RESULTS OF RESEARCH OF GALECTIN-3 AND THYROGLOBULIN IN PATIENTS WITH THYROID NODULES. Grekov's Bulletin of Surgery. 2015;174(2):81-83. (In Russ.) https://doi.org/10.24884/0042-4625-2015-174-2-81-83

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