RESULTS OF DYNAMIC ASSESSMENT OF MELATONIN RECEPTOR EXPRESSION IN LYMPHOCYTES IN PATIENTS WITH ACUTE MILD AND SEVERE PANCREATITIS

Abstract

The authors present results of the investigation of melatonin receptors expression in lymphocytes in dynamics in 102 patients with acute pancreatitis of mild and severe form and in 50 volunteers. A correlated analysis was made between obtained results of laboratory and instrumental researches and clinical course of acute pancreatitis. The decrease of MT₁ receptors expression was noted on 25% in patients with acute pancreatitis. The decline of MT₂ receptors expression was observed on 40% of patients with acute severe pancreatitis and in a case of acute mild pancreatitis — on 15,5%, respectively. Values of MT₁ and MT₂ expression were equal between healthy volunteers. The decline of MT₂ expression was a prognostic unfavourable sign. Obtained results of dynamic expression assessment of MT-receptors were presented as MT₂/MT₁ indices. Given index didn’t change during disease, because of this, the index could be used as a prognostic development marker of destructive form of acute pancreatitis at the moment of patient’s admission to hospital. Mean values of MT2/MT1 were determined for the purpose of universalization of used method (1,13±0,09 for mild form and 0,81±0,09 for severe form of acute pancreatitis, respectively).