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COMPARISON OF THE EFFECTIVENESS OF GENE THERAPY AND STANDARD CONSERVATIVE THERAPY FOR PATIENTS WITH CHRONIC LOWER LIMB ISCHEMIA DUE TO ATHEROSCLEROSIS

https://doi.org/10.24884/0042-4625-2018-177-2-64-69

Abstract

OBJECTIVE. The objective is to compare the effectiveness of standard conservative therapy (SCT) and the complex therapy with preparation based on VEGF165 gene in patients with the stage II of chronic lower limb ischemia according to Fontaine classification during 5 years.

MATERIAL AND METHODS. In total, 92 patients were enrolled in the study. Patients were divided into 2 groups (n=46 for each group). In the first group, patients got only conservative therapy and in the second group, patients were received SCT in combination with injection of gene drug into the ischemic limb muscles.

RESULTS. The using of gene therapy in complex management in patients with the stage II of chronic lower limb ischemia led to significant increasing of the average pain-free walking distance (up to 500 %) (p=0.007). In addition, there were 65 % of the patients in the second group obtaining a significant and moderate improvement. By contrast, there was only 3 % of cases in the first group having similar results with standard therapy. Only gene therapy has statistically significance in the secondary parameters of treatment efficiency.

CONCLUSION. The efficiency of complex treatment with gene therapy in patients with the stage II of ch ronic lower limb ischemia for 5 years exceeds significantly the efficiency of standard conservative therapy.  

About the Authors

Yu. V. Chervyakov
Federal State Budgetary Educational Institution of Higher Education «Yaroslavl State Medical University» of the Ministry of Healthcare of the Russian Federation; State Budgetary Healthcare Institution of Yaroslavl Region «Regional clinical hospital»; «Medical Center for Diagnosis and Prevention plus», Limited Liability Company
Russian Federation
Yaroslavl


O. N. Vlasenko
Federal State Budgetary Educational Institution of Higher Education «Yaroslavl State Medical University» of the Ministry of Healthcare of the Russian Federation
Russian Federation
Yaroslavl


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For citations:


Chervyakov Yu.V., Vlasenko O.N. COMPARISON OF THE EFFECTIVENESS OF GENE THERAPY AND STANDARD CONSERVATIVE THERAPY FOR PATIENTS WITH CHRONIC LOWER LIMB ISCHEMIA DUE TO ATHEROSCLEROSIS. Grekov's Bulletin of Surgery. 2018;177(2):64-69. (In Russ.) https://doi.org/10.24884/0042-4625-2018-177-2-64-69

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