Giant thymolipoma
https://doi.org/10.24884/0042-4625-2020-179-3-75-79
Abstract
Thymolipoma is a rare benign pathological tumor of the anterior mediastinum and accounts for about 2–9 % of thymus tumors. Tumor is usually represented as soft tissue consisting of adipose and thymic tissues. Because of the asymptomatic presentation, patients are often diagnosed with a large tumor. Gigantism of the tumor due to long-term and progressive compression of adjacent organs and anatomical structures of this region can lead to dysfunction, and in some cases, to a complete block of their activity, which is fraught with a fatal outcome. Preoperative diagnosis is always a difficult task due to the lower sensitivity of CT scans and biopsies. The main method of treatment is radical surgical excision. The article presents a clinical case of a 51-year-old patient with a giant tumor of the left hemithorax with a long-term asymptomatic presentation, who was diagnosed with thymolipoma after surgical excision and final histopathological examination.
About the Authors
E. O. RodionovRussian Federation
Rodionov Evgenii O., Cand. of Sci. (Med.), Senior Researcher, Thoracic Department, Cancer Research Institute; Assistant of the Department of Oncology.
5, Kooperativniy per., Tomsk, 634009, Russia.
S. V. Miller
Russian Federation
Miller Sergey V., Dr. of Sci. (Med.), Leading Researcher, Thoracic Department, Cancer Research Institute
Tomsk
N. V. Vasilyev
Russian Federation
Vasilyev Nikolay V., Cand. of Sci. (Med.), Senior Researcher, Department of General and Molecular Pathology, Cancer Research Institute
Tomsk
S. A. Tuzikov
Russian Federation
Tuzikov Sergey A., Dr. of Sci. (Med.), Professor, Head of Thoracic Department, Cancer Research Institute; Professor of the Department of Oncology
Tomsk
I. G. Frolova
Russian Federation
Frolova Irina G., Dr. of Sci. (Med.), Professor, Head of the Diagnostic Imaging Department, Cancer Research Institute
Tomsk
O. I. Kovalev
Russian Federation
Kovalev Oleg I., Resident Physician of the Department of Pathological Anatomy
Tomsk
A. A. Silantyeva
Russian Federation
Silantyeva Alyena A., 6-year student at the Faculty of Medicine
Tomsk
S. I. Ponomareva
Russian Federation
Ponomareva Saina I., 5-year student at the Faculty of Medicine
Tomsk
References
1. Feng Z., Li M., Liu F. et al. Analysis of giant thoracic neoplasms: correlations between imaging, pathology and surgical management. Thoracic Cancer. 2017;8(5):402–409. Doi: 10.1111/1759-7714.12448.
2. Efteev L. A., Rodionov E. O., Miller S. V. Videotorakoskopiya v kombinirovannom lechenii timom. Khirurgiya. Zhurnal im. N. I. Pirogova. 2019;(3):84–87. (In Russ.). Doi: 10.17116/hirurgia201903184.
3. Sunam G. S., Öncel M., Ceran S. et al. Giant benign mediastinal masses extending into the pleural cavity. Surg J (N Y). 2016;2(2):e46–e50. Doi: 10.1055/s-0036-1584519.
4. Travis W. D., Brambilla E., Burke A. P. et al. WHO Classification of tumours of the lung, pleura, thymus and heart. IARC, Lyon, 2015:412.
5. Rao P. S. M., Moorthy N., Shankarappa R. K. et al. Giant mediastinal thymolipoma simulating cardiomegaly. J Cardiol. 2009;54(2):326–329. Doi: 10.1016/j.jjcc.2008.12.008.
6. Carillo G. A. O., Fontоn E. M. G., Carretero M. Е. C. Giant thymolipoma: case report of an unusual mediastinal tumor. Arch Bronconeumol. 2014;50(12):557–559. Doi: 10.1016/j.arbres.2013.11.028.
7. Eida H. A., Alib A. E., Elsabryb M. A. Enormous thymolipoma: а case report. Egypt J Bronchol. 2017;11(2):165–167. Doi: 10.4103/1687-8426.203799.
8. Kucuk C., Arda K., Ata N. et al. Atypical presentation of thymolipoma. Chest Disease Reports. 2016;4(1):5634:1–2.
9. Mourad O. M. A., de Andrade F. M., Abrahão P., Monnerat A. et al. Asymptomatic giant mediastinal mass: a rare case of thymolipoma. J Bras Pneumol. 2009;35(10):1049–1052.
10. Goswami A., Baruah A. R. Giant thymolipoma: a rare case presentation. Asian Cardiovasc. Thorac. Ann. 2017;25(2):143–145. Doi: 10.1177/0218492315599689.
11. Rieker R. J., Schirmacher P., Schnabel P. A. et al. Thymolipoma. A report of nine cases, with emphasis on its association with myasthenia gravis. Surg Today. 2010;40(2):132–136.
12. Hussain B. S., Reddy S. V. Giant Thymolipoma – A rare benign tumour of the thymus gland. Indian Journal of Mednodent and Allied Sciences. 2015;3(1):59–62.
13. Sharma K. C., Bhakuni Y. S., Darlong L. M. et al. A giant mediastinal thymolipoma: a rare pathological entity. Indian J Thorac Cardiovasc Surg. 2019;35:115–117. Doi: 10.1007/s12055-018-0700-9.
Review
For citations:
Rodionov E.O., Miller S.V., Vasilyev N.V., Tuzikov S.A., Frolova I.G., Kovalev O.I., Silantyeva A.A., Ponomareva S.I. Giant thymolipoma. Grekov's Bulletin of Surgery. 2020;179(3):75-79. (In Russ.) https://doi.org/10.24884/0042-4625-2020-179-3-75-79