The level of serum matrix metalloproteinase and its prognostic value in closed injuries of the spleen in the immediate postoperative period

The OBJECTIVE was to study the state of serum matrix metalloproteinase and their prognostic value in closed spleen injuries in the immediate postoperative period.

METHODS AND MATERIALS. Retrospective analysis of the course of the immediate postoperative period of 126 patients with closed spleen injuries was carried out in this work. They were treated in the emergency surgery department. Taking into account that the main leading factor affecting the immediate postoperative period in such patients is the time factor, i.e. the time of delivery to the medical institution from the moment of injury, we divided all patients into two groups: group A – the time of delivery to the medical institution did not exceed one hour from the moment of injury. This group was divided into two subgroups: А1 – isolated injuries and А2 – combined injuries. The second group, group B, included patients whose delivery time exceeded one hour, which were also divided into two subgroups: B1 – isolated injuries and B2 – combined injuries. During the study, the level of the tissue inhibitor of metalloproteinases-1 (TIMP-1), matrix metalloproteinases-2, -7, -9 (MMPs-2, -7, -9) in blood serum was determined.

RESULTS. As a result of the study, it was found that changes in TIMP-1 and MMPs-2, -7, -9 in blood serum depend on the time of delivery of the patient and the presence or absence of combined lesions.

CONCLUSION. Changes in levels of the tissue inhibitor of metalloproteinases-1, matrix metalloproteinases-2, -7, -9 can be considered as predictors of development of complications and fatal outcomes in patients with closed spleen injuries in the immediate postoperative period. Changes in these indicators depend on the time of delivery of the patient and the nature of the injury. The reduction of the tissue inhibitor of metalloproteinases below 1231 ng/ml is an unfavourable indicator of death.

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