Preview

Grekov's Bulletin of Surgery

Advanced search

Prevention and treatment of wound infections after caesarean section

https://doi.org/10.24884/0042-4625-2022-181-5-70-77

Abstract

Caesarean section (cS) is one of the most common obstetric operations in the world. About 32 % of all births end by caesarean section. Postpartum infection at the surgical site, wound infection and endometritis are the main causes of long stays in maternity hospitals and are a source of additional costs for the healthcare system. In 2–16 % of cases postpartum endometritis develops. Many risk factors for the development of postpartum infections have been described. These include maternal factors (such as tobacco use, inadequate prenatal care, obesity, corticosteroid use; prematurity, multiple gestation, and uterine scar), intrapartum and operative factors (such as chorioamnionitis; premature rupture of membranes; prolonged anhydrous period; prolonged labor , especially a long second period; large incision of the anterior abdominal wall; subcutaneous tissue thickness more than 3 cm; subcutaneous hematoma; lack of antibiotic prophylaxis; rapid labor; massive blood loss during childbirth). Effective measures to reduce the incidence of obstetric infectious complications include prophylactic use of antibiotics (preoperative preparation with first-generation cephalosporins and intravenous azithromycin), preoperative showering with chlorhexidine instead of iodine, shaving immediately before surgery, vaginal sanitation, removal of the placenta by traction of the umbilical cord, suturing of the subcutane-ous tissue, if the depth of the wound is larger than 2 cm and suturing the skin with sutures instead of using staples. Establishing an evidence-based optimal care algorithm for patients after caesarean section can reduce the incidence of serious infectious complications.

About the Authors

K. Yu. Krylov
St. Luke’s clinical Hospital
Russian Federation

Krylov Kirill Yu., Cand. of Sci. (Med.), Obstetrician-Gynecologist, Head of Gynecology Department

46, build. A, chugunnaia str., Saint Petersburg, 194044


Competing Interests:

The authors declare no conflict of interest.



N. N. Rukhliada
Saint-Petersburg State Pediatric Medical University
Russian Federation

Rukhliada Nikolaj N., Dr. of Sci. (Med.), Professor, Head of the Department of Obstetrics and Gynecology

Saint Petersburg


Competing Interests:

The authors declare no conflict of interest.



E. I. Biryukova
Saint-Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine
Russian Federation

Biryukova Elena I., Cand. of Sci. (Med.), Obstetrician-Gynecologist, Head of the Department of Gynecology № 2

Saint Petersburg


Competing Interests:

The authors declare no conflict of interest.



L. Sh. Tsechoeva
Saint-Petersburg I. I. Dzhanelidze Research Institute of Emergency Medicine
Russian Federation

Tsechoeva Lejla Sh., Cand. of Sci. (Med.), Obstetrician-Gynecologist, Head of the Department of Gynecology № 1

Saint Petersburg


Competing Interests:

The authors declare no conflict of interest.



References

1. Matukhin V. I., Malyshava A. A., Reznik V. A., Rukhlyada N. N., Taits A. N., Krylov K. Yu., Novitskaya N. Yu. Hypothesis of formation of an inconsistent uterine scar after cesarean section as a risk factor for placental ingrowth // Problems of Reproduction. 2020;26(6):114–121. (In Russ.).

2. Liu S., Liston R. M., Joseph K. S. et al. Maternal mortality and severe morbidity associated with low-risk planned cesarean delivery versus planned vaginal delivery at term // CMAJ. 2007;176(4):455–60.

3. Mackeen A. D., Khalifeh A., Fleisher J. et al. Suture compared with staple skin closure after cesarean delivery: a randomized controlled trial // Obstet Gynecol. 2014;123(6):1169–75.

4. Wechter M. E., Pearlman M. D., Hartmann K. E. Reclosure of the disrupted laparotomy wound: a systematic review // Obstet Gynecol. 2005;106:376–83.

5. Blumenfeld Y. J., El-Sayed Y. Y., Lyell D. J. et al. Risk factors for prolonged postpartum length of stay following cesarean delivery // Am J Perinatol. 2015; 32(9):825–32.

6. Martens M. G., Kolrud B. L., Faro S. et al. Development of wound infection or separation after cesarean delivery. Prospective evaluation of 2,431 cases // J Reprod Med. 1995;40:171–5.

7. Goepfert A. R., Guinn D. A., Andrews W. W. et al. Necrotizing fasciitis after cesarean delivery // Obstet Gynecol. 1997;89(3):409–12.

8. Stevens D. L., Bisno A. L., Chambers H. F. et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America // Clin Infect Dis. 2014;59(2):147–59.

9. Rosene K., Eschenbach D. A., Tompkins L. S. et al. Polymicrobial early postpartum endometritis with facultative and anaerobic bacteria, genital mycoplasmas, and Chlamydia trachomatis: treatment with piperacillin or cefoxitin // J Infect Dis. 1986;153(6):1028.

10. Guzman M. A., Prien S. D., Blann D. W. Post-cesarean related infection and vaginal preparation with povidone-iodine revisited // Primary Care Update OB/GYNS. 2002;9(6):206–9.

11. Tran T. S., Jamulitrat S., Chongsuvivatwong V. et al. Risk factors for postcesarean surgical site infection // Obstet Gynecol. 2000;95(3):367–71.

12. Avila C., Bhangoo R., Figueroa R. et al. Association of smoking with wound complications after cesarean delivery // J Matern Fetal Neonatal Med. 2012;25:1250–3.

13. Jama F. E. Risk factors for wound infection after lower segment cesarean section // Qatar Med J. 2012;2:26–31.

14. De Vivo A., Mancuso A., Giacobbe A. et al. Wound length and corticosteroid administration as risk factors for surgical-site complications following cesarean section // Acta Obstet Gynecol Scand. 2010;89(3):355–9.

15. Killian C. A., Graffunder E. M., Vinciguerra T. J. et al. Risk factors for surgical-site infections following cesarean section // Infect Control Hosp Epidemiol. 2001;22:613–7.

16. Wloch C., Wilson J., Lamagni T. et al. Risk factors for surgical site infection following caesarean section in England: results from a multicentre cohort study // BJOG. 2012;119(11):1324–33.

17. Opøien H. K., Valbø A., Grinde-Andersen A. et al. Post-cesarean surgical site infections according to CDC standards: rates and risk factors. A prospective cohort study // Acta Obstet Gynecol Scand. 2007;86(9):1097–102.

18. Schneid-Kofman N., Sheiner E., Levy A. et al. Risk factors for wound infection following cesarean deliveries // Int J Gynaecol Obstet. 2005;90:10–5.

19. Vermillion S. T., Lamoutte C., Soper D. E. et al. Wound infection after cesarean: effect of subcutaneous tissue thickness // Obstet Gynecol. 2000;95(6 Pt 1):923–6.

20. Tuuli M. G., Liu L., Longman R. E. et al. Infectious morbidity is higher after second-stage compared with first-stage cesareans // Am J Obstet Gynecol. 2014;211(4):410.e1–6.

21. Takoudes T. C., Weitzen S., Slocum J. et al. Risk of cesarean wound complications in diabetic gestations // Am J Obstet Gynecol. 2004;191(3):958–63.

22. Chaim W., Bashiri A., Bar-David J. et al. Prevalence and clinical significance of postpartum endometritis and wound infection // Infect Dis Obstet Gynecol. 2000;8:77–82.

23. Olsen M. A., Butler A. M., Willers D. M. et al. Comparison of costs of surgical site infection and endometritis after cesarean delivery using claims and medical record data // Infect Control Hosp Epidemiol. 2010;31:872–5.

24. Smaill F. M., Grivell R. M. Antibiotic prophylaxis versus no prophylaxis for preventing infection after cesarean section // Cochrane Database of Systematic Reviews. 2014;10:CD007482.

25. Sullivan S. A., Smith T., Chang E. et al. Administration of cefazolin prior to skin incision is superior to cefazolin at cord clamping in preventing postcesarean infectious morbidity: a randomized, controlled trial // Am J Obstet Gynecol. 2007;196:455.e1–5.

26. Thigpen B. D., Hood W. A., Chauhan S. et al. Timing of prophylactic antibiotic administration in the uninfected laboring gravida: a randomized clinical trial // Am J Obstet Gynecol. 2005;192:1864–71.

27. Wax J. R., Hersey K., Philput C. et al. Single dose cefazolin prophylaxis for postcesarean infections: before vs after cord clamping // J Matern Fetal Med. 1997;6:61–5.

28. Owens S. M., Brozanski B. S., Meyn L. A. et al. Antimicrobial prophylaxis for cesarean delivery before skin incision // Obstet Gynecol. 2009;114(3):573–9.

29. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 120: use of prophylactic antibiotics in labor and delivery // Obstet Gynecol. 2011;117(6):1472–83.

30. Ahmadzia H. K., Patel E. M., Joshi D. et al. Obstetric surgical site infections: 2 grams compared with 3 grams of Cefazolin in morbidly obese women // Obstet Gynecol. 2015;126(4):708–15.

31. Tita A. T., Hauth J. C., Grimes A. et al. Decreasing incidence of postcesarean endometritis with extended-spectrum antibiotic prophylaxis // Obstet Gynecol. 2008;111(1):51–6.

32. Echebiri N. C., McDoom M. M., Aalto M. M. et al. Prophylactic use of negative pressure wound therapy after cesarean delivery // Obstet Gynecol. 2015;125(2):299–307.

33. Ngai I. M., Van Arsdale A., Govindappagari S. et al. Skin preparation for prevention of surgical site infection after cesarean delivery: a randomized controlled trial // Obstet Gynecol. 2015;126(6):1251–7.

34. Atkinson M. W., Owen J., Wren A. et al. The effect of manual removal of the placenta on post-cesarean endometritis // Obstet Gynecol. 1996;87(1):99–102.

35. Viney R., Isaacs C., Chelmow D. Intraabdominal irrigation at cesarean delivery: a randomized controlled trial // Obstet Gynecol. 2012;120:708.

36. Yildirim G., Güngördük K., Asicioğlu O. et al. Does vaginal preparation with povidone-iodine prior to caesarean delivery reduce the risk of endometritis? A randomized controlled trial // J Matern Fetal Neonatal Med. 2012;25(11):2316–21.

37. Tuuli M. G., Liu J., Stout M. J. et al. A randomized trial comparing skin antiseptic agents at cesarean delivery // N Engl J Med. 2016;374(7):647–55.

38. American College of Obstetricians and Gynecologists Women’s Health Care Physicians, Committee on Gynecologic Practice. Committee opinion no. 571: solutions for surgical preparation of the vagina // Obstet Gynecol. 2013;122(3):718–20.

39. Walsh C. A., Walsh S. R. Extraabdominal vs intraabdominal uterine repair at cesarean delivery: a metaanalysis // Am J Obstet Gynecol. 2009;200(6):625.e1–8.

40. Tanner J., Norrie P., Melen K. Preoperative hair removal to reduce surgical site infection // Cochrane Database Syst Rev. 2011;(11):CD004122.

41. Ahmed M. R., Aref N. K., Sayed Ahmed W. A. et al. Chlorhexidine vaginal wipes prior to elective cesarean section: does it reduce infectious morbidity? A randomized trial // J Matern Fetal Neonatal Med. 2016;1:1–4.

42. Harrigill K. M., Miller H. S., Haynes D. E. The effect of intraabdominal irrigation at cesarean delivery on maternal morbidity: a randomized trial // Obstet Gynecol. 2003;101(1):80–5.

43. Haas D. M., Morgan S., Contreras K. Vaginal preparation with antiseptic solution before cesarean section for preventing postoperative infections // Cochrane Database Syst Rev. 2014;(9):CD007892.

44. Johnson M. P., Kim S. J., Langstraat C. L. et al. Using bundled interventions to reduce surgical site infection after major gynecologic cancer surgery // Obstet Gynecol. 2016;127(6):1135–44.

45. Hellums E. K., Lin M. G., Ramsey P. S. Prophylactic subcutaneous drainage for prevention of wound complications after cesarean delivery – a metaanalysis // Am J Obstet Gynecol. 2007;197(3):229–35.

46. Postoperative complications // Diagnosis & Treatment: surgery, 13 th edition / eds. by Doherty G. M. New York, McGraw-Hill, 2010.

47. Ubbink D. T., Westerbos S. J., Evans D. et al. Topical negative pressure for treating chronic wounds // Cochrane Database Syst Rev. 2008;(3): CD001898.

48. Swift S. H., Zimmerman M. B., Hardy-Fairbanks A. J. Effect of single-use negative pressure wound therapy on Postcesarean infections and wound complications for high-risk patients // J Reprod Med. 2015;60(5–6):211–8.

49. Chelmow D., Rodriguez E. J., Sabatini M. M. Suture closure of subcutaneous fat and wound disruption after cesarean delivery: a meta-analysis // Obstet Gynecol. 2004;103(5 Pt 1):974–80.

50. Stevens D. L., Bisno A. L., Chambers H. F. et al. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the infectious diseases society of America // Clin Infect Dis. 2014;59(2):147–59.

51. Darenberg J., Ihendyane N., Sjölin J. et al. Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial // Clin Infect Dis. 2003;37(3):333–40.


Supplementary files

Review

For citations:


Krylov K.Yu., Rukhliada N.N., Biryukova E.I., Tsechoeva L.Sh. Prevention and treatment of wound infections after caesarean section. Grekov's Bulletin of Surgery. 2022;181(5):70-77. (In Russ.) https://doi.org/10.24884/0042-4625-2022-181-5-70-77

Views: 891


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 0042-4625 (Print)
ISSN 2686-7370 (Online)