SUBSTANTIATION OF APPLICATION OF ALLOGENIC FIBROBLASTS IN TREATMENT OF EXTENSIVE BURNS
https://doi.org/10.24884/0042-4625-2017-176-1-42-45
Abstract
Recent researches left no doubt in clinical efficacy of allogenic fibroblasts transplantation in case of burn treatment. There are several problems concerning indications and terms of transplantation performance of cell culture in treatment of boundary burns. The authors would like to prove an application of allogenic fibroblast culture in surgical treatment of victims with extensive dermal burns. The authors analyzed the results of surgical treatment of 36 miners, who were cured in burn department of V.K. Gusak Institute of Emergency and Plastic Surgery (Donetsk) at the period from 2004 to 2013. It was found that the application of fetal allogenic fibroblasts reduced the number of repeated autoplasty on 36% in main group of patients due to optimization of wound healing in case of burns.
About the Authors
E. Ya. Fistal’
V.K. Gusak Institute of Emergency and Plastic Surgery
Russian Federation
Russian Federation
V. V. Soloshenko
V.K. Gusak Institute of Emergency and Plastic Surgery
Russian Federation
Russian Federation
References
1. Алексеев А. А., Салахиддинов К. З., Гаврилюк Б. К., Тюрников Ю. И. Комплексное лечение глубоких ожогов на основе применения хирургической некрэктомии и современных биотехнологических методов и современных биотехнологических методов // Анналы хирургии. 2012. № 2. С. 41-45.
2. Алексеев А. А. Яшин А. Ю. Комбинированная аутодермопластика с трансплантацией культивированных фибробластов при обширных глубоких ожогах; клинические результаты и перспективы // Материалы междунар. симпозиума. Тула, 1996. С. 1-3.
3. Расулов М. Ф., Василенко В. Т., Зайденов В. А. Клеточная трансплантация подавляет воспалительную реакцию и стимулирует репаративные процессы в ожоговой ране // Бюл. экспер. биол. 2006. Т. 1, № 142. С. 112-115.
4. Таричко Ю. В. Хирургия без донорской крови // Хирургия. 2004. № 10. С. 63-67.
5. Böttcher-Haberzeth S., Reichmann E. Tissue engineering of skin // Burns. 2010. Vol. 36, № 4. Р. 450-460.
6. Nedelec B., De Oliveira А., Saint-Cyr M., Garrel D. Differential effect of burn injury on fibroblasts from wounds and normal skin // Plast Reconstr Surg. 2007. Vol. 119, № 7. Р. 2101-2109.
7. Paeura M., Kaartinen I., Suomela S. Improved skin wound epithelialization by topical delivery of soluble factors from fibroblast aggregates // Burns. 2012. Vol. 38, № 4. Р. 541-550.
8. Price R. D., Das-Gupta V., Harris P.A. et al. The role of allogenic fibroblasts in an acute wound healing model // Plast. Reconstr. Surg. 2004. Vol. 113. P. 1719-1729.
9. Wong T., McGrath J. A., Navsaria H. The role of fibroblasts in tissue engineering and regeneration // Br. J. Dermatol. 2007. Vol. 156. P. 1149-1155.
Review
For citations:
Fistal’ E.Ya., Soloshenko V.V. SUBSTANTIATION OF APPLICATION OF ALLOGENIC FIBROBLASTS IN TREATMENT OF EXTENSIVE BURNS. Grekov's Bulletin of Surgery. 2017;176(1):42-45. (In Russ.) https://doi.org/10.24884/0042-4625-2017-176-1-42-45
Views:
538
Email this article 