EFFICACY OF DERMOPLASTY AND THE DERMAL EQUIVALENT IN TREATMENT OF VAST LEG ULCERS OF MIXED GENESIS
https://doi.org/10.24884/0042-4625-2013-172-1-104-107
Abstract
The most frequent causes of leg ulcers (90–95%) are chronic venous insufficiency (45–60%), obliterating atherosclerosis of the lower extremity arteries (10–20%), diabetes mellitus (15– 25%) and their combinations (10–15%).The leg ulcers, specified as pyoderma gangrenosum, are the rare and severe pathology, which is very often misdiagnosed. The case history of a 58-year old female patient with vast leg ulcers of the both shanks is analyzed. The leg ulcers were caused by pyoderma gangrenosum and chronic venous insufficiency due to the varicose disease. Complete epithelization of both ulcers was achieved by means of dermoplasty combined using the dermal equivalent against the background of system immunosuppressive therapy.
About the Authors
D. Yu. Andreev
State Pavlov Medical University; Institute of Cytology of the Russian Academy of Sciences
Russian Federation
Russian Federation
N. V. Abramova
State Pavlov Medical University; Institute of Cytology of the Russian Academy of Sciences
Russian Federation
Russian Federation
M. I. Blinova
State Pavlov Medical University; Institute of Cytology of the Russian Academy of Sciences
Russian Federation
Russian Federation
G. P. Pinaev
State Pavlov Medical University; Institute of Cytology of the Russian Academy of Sciences
Russian Federation
Russian Federation
References
1. Блинова М. И., Калмыкова Н. В., Юдинцева Н. М. и др. Использование культивируемых клеток кожи человека для лечения трофических язв // Информ. бюл. «Клеточные культуры». 2006. Вып. 21. С. 33–44.
2. Григорян А. С. Фибробласты в качестве иммуносупрессоров — функциональный эквивалент мультипотентных мезенхимальных стромальных клеток // Клеточная трансплантология. 2007. № 2. С. 24–25.
3. Мельцова А. Ж., Гриценко В. В., Орловский П. И. и др. Применение дермальных фибробластов в комплексном лечении больных трофическими язвами венозной этиологии // Вестн. хир. 2007. № 1. С. 72–77.
4. Мельцова А. Ж., Сабельников В. В., Гриценко В. В. и др. Применение аллогенных дермальных фибробластов в комплексном лечении трофических язв венозной этиологии // Стационарозамещающие технологии. Амбулаторная хирургия. 2005. № 3. С. 34–36.
5. Dwarakanath A. D., Yu L. G., Brookes C. et al. Sticky neutrophils, pathergic arthritis, and response to heparin in pyoderma gangrenosum complicating ulcerative colitis // Gut. 1995. Vol. 37, № 4. P. 585–588.
6. Hafner J., Kühne A., Trüeb R. M. Successful grafting with EpiDex in pyoderma gangrenosum // Dermatology. 2006. Vol. 212, № 3. P. 258–259.
7. Powell F. C., Schroeter A. L., Su W. P., Perry H. O. Pyoderma gangrenosum: a review of 86 patients // Q. J. Med. 1985. Vol. 55, № 217. P. 173–186.
8. Powell F. C., Su W. P., Perry H. O. Pyoderma gangrenosum: Classification and management // J. Am. Acad. Dermatol. 1996. Vol. 34, № 3. P. 395–409.
9. Wollina U. Pyoderma gangrenosum — a review // Orphanet J. Rare Dis. 2007. Vol. 2. P. 19.
Review
For citations:
Andreev D.Yu., Abramova N.V., Blinova M.I., Pinaev G.P. EFFICACY OF DERMOPLASTY AND THE DERMAL EQUIVALENT IN TREATMENT OF VAST LEG ULCERS OF MIXED GENESIS. Grekov's Bulletin of Surgery. 2013;172(1):104-107. (In Russ.) https://doi.org/10.24884/0042-4625-2013-172-1-104-107
Views:
402
Email this article 