Pathophysiological aspects of blood transfusion for patients with liver cirrhosis
https://doi.org/10.24884/0042-4625-2019-178-1-86-89
Abstract
To date, there are no clear indications and reasons for transfusion therapy in patients with cirrhosis. The article discusses the basic pathophysiological changes in the patient’s body during the formation of the liver cirrhosis as the outcome of hepatitis of different etiology. Particular attention is given to a component of donor plasma fibronectin, the lack of which, including in patients with liver cirrhosis, causes progressing endotoxemia.
Keywords
liver cirrhosis,
endotoxin,
endotoxemia,
Kupfer cells,
fibronectin,
anemia,
coagulopathy,
thrombocytopenia
About the Authors
E. Iu. Lazareva
Clinical Infectious Diseases Hospital named after S. P. Botkin
Russian Federation
Corresponding author: Elizaveta Iu. Lazareva, Clinical Infectious Diseases Hospital named after S. P. Botkin, 49 Piskarevskii street, St. Petersburg, Russia
Russian Federation
Corresponding author: Elizaveta Iu. Lazareva, Clinical Infectious Diseases Hospital named after S. P. Botkin, 49 Piskarevskii street, St. Petersburg, Russia
A. V. Koloskov
North-Western State Medical University named after I. I. Mechnikov
Russian Federation
Russian Federation
Andrei V. Koloskov
St. Petersburg
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For citations:
Lazareva E.I., Koloskov A.V. Pathophysiological aspects of blood transfusion for patients with liver cirrhosis. Grekov's Bulletin of Surgery. 2019;178(1):86-89. (In Russ.) https://doi.org/10.24884/0042-4625-2019-178-1-86-89
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