Preview

Grekov's Bulletin of Surgery

Advanced search

PECULARITIES OF SURGICAL APPROACH IN TREATMENT OF GASTROINTESTINAL STROMAL TUMORS

https://doi.org/10.24884/0042-4625-2017-176-2-22-27

Abstract

OBJECTIVE. The authors made an analysis of short-term results of surgical treatment of the patients with gastrointestinal stromal tumors. MATERIALS AND METHODS. The data of medical histories of 94 patients were analyzed. The traditional, laparoscopic and endoscopic interventions were performed on the patients in order to remove the stromal tumors of the stomach and small intestine using radical methods. RESULTS. All surgeries (100 % of patients) were carried out in an adequate volume. There wasn’t noted the postoperative mortality and statistical difference of length of hospital stay (13,1 bed days after laparotomy and 11,5 bed days after minimally invasive interventions). The rate of early postoperative complications was higher after endoscopic interventions. CONCLUSIONS. Minimally invasive methods as well as traditional interventions are radical methods of treatment of gastrointestinal stromal tumors. An application of diverse and non-standardized approaches requires both the development of interdisciplinary collaboration and creation of optimal algorithm for choice of specific surgical technique based on localization, size and type of tumor growth in order to improve safety and reliability of treatment.

About the Authors

V. A. Kashchenko
St. Petersburg State University; L. G. Sokolov Clinical Hospital № 122
Russian Federation


A. M. Karachun
N. N. Petrov Research Institute of Oncology
Russian Federation


R. V. Orlova
St. Petersburg State University
Russian Federation


Yu. V. Pelipas’
N. N. Petrov Research Institute of Oncology
Russian Federation


V. V. Petrova
St. Petersburg State University; St. Petersburg Multifield Centre
Russian Federation


S. L. Nepomnyashchaya
St. Petersburg Multifield Centre
Russian Federation


M. I. Gluzman
St. Petersburg State University; L. G. Sokolov Clinical Hospital № 122
Russian Federation


E. G. Beskrovnyi
St. Petersburg State University
Russian Federation


References

1. Карачун А. М., Орлова Р. В., Пелипась Ю. В. и др. Современные представления об особенностях хирургического лечения гастроинтестинальных стромальных опухолей // Клиническая больница 122. 2016. Вып. 16. C. 48-57.

2. Онкология: Национальное руководство. Краткое издание / Под ред. В. И. Чиссова, М. И. Давыдова. М.: ГЭОТАР-Медиа, 2014. 576 с.

3. Dagher R., Cohen M., Williams G. et al. Approval summary: imatin ibmesylate in the treatment of metastatic and/or unresectable malignant gastrointestinal stromal tumors // Clin. Cancer Res. 2002. Vol. 8. P. 3034-3038.

4. Demetri G. D., Antonescu C. R., DeMatteo R. P. et al. NCCN Task Force report: update on the management of patients with gastrointestinal stromaltumors // J. Natl. Compr. Canc. Netw. 2010. Vol. 8. Suppl. 2. P. 1-41

5. Edge S. B., Byrd D. R., Compton C. C. et al. Gastrointestinal stromal tumor: AJCC Cancer Staging Manual. 7th ed. New York: Springer, 2010. P. 175-180.

6. Gasali P. G., Blay J.-Y., Bertuzzi A. et al. Gastrointestinal stromal tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up // Ann. Oncol. 2014. Vol. 25. Suppl. 3. P. 21-26.

7. Ghanem N., Altehoefer C., Furtwangler A. et al. Computed tomography in gastrointestinal stromal tumors // Eur. Radiol. 2003. Vol. 13. P. 1669-1678.

8. Hirota S., Isozaki K., Moriyama Y. et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors // Science 1998. Vol. 279. P. 577-580.

9. Lin J., Huang C., Zheng C. et al. Laparoscopic versus open gastric resection for larger than 5 cm primary gastric gastrointestinal stromal tumors (GIST): a size-matched comparison // Surg. Endosс. 2014. Vol. 28, № 9. P. 2577-2583.

10. Miettinen M., Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites // Semin. Diagn. Pathol. 2006. Vol. 23. P. 70-83.

11. Miettinen M., Lasota J. Gastrointestinal stromal tumors // Gastroenterol. Clin. North. Amer. 2013. Vol. 42, № 2. P. 399-415.

12. Nishida T., Hirota S., Yanagisawa A. et al. Clinical practice guidelines for gastrointestinal stromal tumor (GIST) in Japan: English-version // Int. J. Clin. Oncol. 2008. Vol. 13, № 5. P. 416-430.

13. Rosch T., Kapfer B., Will U. Accuracy of endoscopic ultrasonography in upper gastrointestinal submucosal lesions: a prospective multicenter study // Scand. J. Gastroenterol. 2002. № 37. P. 856-862.

14. Tsujimoto H., Yaguchi Y., Kumano I. et al. Successful gastric submucosal tumor resection using laparoscopic and endoscopic cooperative surgery // World J. Surg. 2012. Vol. 36. P. 327-330.

15. Valsangkar N., Sehdev A., Misra S. et al. Current management of gastrointestinal stromal tumors: surgery, current biomarkers, muta tions, and therapy: Review Article // Surgery. 2015. Vol. 158. P. 1149-1164.


Review

For citations:


Kashchenko V.A., Karachun A.M., Orlova R.V., Pelipas’ Yu.V., Petrova V.V., Nepomnyashchaya S.L., Gluzman M.I., Beskrovnyi E.G. PECULARITIES OF SURGICAL APPROACH IN TREATMENT OF GASTROINTESTINAL STROMAL TUMORS. Grekov's Bulletin of Surgery. 2017;176(2):22-27. (In Russ.) https://doi.org/10.24884/0042-4625-2017-176-2-22-27

Views: 559


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 0042-4625 (Print)
ISSN 2686-7370 (Online)